DHEA cream versus pill: Why use DHEA as a cream?

DHEA is short for dehydroepiandrosterone. It is the most abundant naturally occurring pro-hormone in the human body. It is not a foreign substance. It is a natural hormone precursor that only occurs in humans. In this article we explore the main difference of DHEA cream vs pills and why an absorbable DHEA cream supplement is more effective and safer. It is what the body uses naturally provided where the body uses it.

For people 35 and up, Twist 25 DHEA supplement cream is the best way to maintain healthy hormones and enjoy the various health and psychological benefits DHEA offers.

DHEA was first identified in 1931 by Dr. Adolf Butenandt, who was awarded the Nobel Prize for Chemistry in 1939. Frequently called “the anti-aging hormone”, DHEA is a base for more than 50 hormones that are smaller or more specific carbon chain molecules in human biochemistry. As a precursor for all estrogenic and androgenic hormones, humans make DHEA naturally from birth.

DHEA is the most abundant foundation or base from which the body makes hormones. DHEA is produced and metabolized in the adrenal glands, gonads, and dermis. This is why using DHEA as an absorbable skin cream makes sense, rather than swallowing a DHEA pill.

It is important to understand why using DHEA as a properly made absorbable skin cream rather than a pill makes sense. Absorbable DHEA delivered by a special coconut oil base cream. Let’s explore the science.

DHEA levels over the human lifespan

DHEA levels increase from birth through adolescence and puberty and peak between ages 20-25, when we are “in our prime”. Then DHEA levels gradually decrease by about 2% per year thereafter. So, by age 35, the body produces about 20% less DHEA than when we were “in our prime” at age 25; and by age 50, we produce 50% less DHEA than we did when we were in our twenties. This gradual decline continues.

Human DHEA levels with age
DHEA levels over human lifespan compared to maintaining DHEA levels











 Men and women produce more and more DHEA every year to about age 25 when levels are at their peak. After age 25, DHEA levels begin to decline at a rate of about two percent per year thereafter.

What does DHEA do?

One of the primary roles of DHEA is as a base hormone precursor. DHEA also supports the immune system, allowing for a greater number of and activity of natural killer (NK) cells. Low DHEA levels are associated with many diseases of aging, such as cardiovascular disease, cancer, osteoporosis, depression, and dementia.

DHEA promotes tissue formation after exercise, and counterbalances the inflammatory effects of cortisol. So it helps reduce soreness after workouts and helps us rebuild muscle, cartilage and bone. DHEA also serves as a base for sebum (skin oil), protecting skin cells from both UV and chemical carcinogens. In addition, DHEA stimulates the formation of connective tissue and cartilage and improves bone strength.

DHEA supports:

  • Energy, focus and mental acuity
  • Immune system
  • Lean muscle tone
  • Bone strength
  • Cardiovascular health
  • Libido and sexual performance
  • Deep REM sleep
  • Softer, more hydrated skin

DHEA reduces:

  • Abdominal Fat
  • Risk of Cancer
  • Risk of Cardiovascular Disease
  • Fatigue
  • Depression
  • Poor quality sleep
  • Joint pain
  • Muscle soreness

It is not possible to eat any particular foods to increase DHEA. DHEA supplementation is generally recommended for people 35 and up to maintain health.

Listen to our podcast on why DHEA Cream is an important Health Strategy. We explain what DHEA is and why supplementing DHEA using a properly made absorbable skin cream called Twist 25 is great for women and men 35 and up. Benefits include cardiovascular health, immune system support, counterbalancing cortisol, the stress hormone, reducing fat and inflamation… Listen here.


DHEA cream vs pills: Why Twist 25 DHEA cream works

As mentioned above, the human body naturally metabolizes DHEA in the dermis. Twist 25 cream provides what the body uses naturally, bioidentical DHEA, where the body used it, in the dermis or skin, the largest organ of the human body. Twist 25 cream yields noticeable benefits within a few weeks. DHEA is much less effective when taken as a pill because most DHEA is eliminated by the liver.

Twist 25 DHEA Cream instead of a pill

There are 3 key reasons for this:

#1 When DHEA is taken orally as a pill, most DHEA is eliminated by the “First-pass effect” of the liver. Basically, the liver filters out most of the effective DHEA before it can do any good; and what does end up increasing in the bloodstream is DHEA-S (DHEA sulfate), not free DHEA. Free DHEA is truly the base from which the sex hormones are metabolized. These androgenic and estrogenic hormones are the hormones that help us to feel good.

#2 DHEA-S is not the same as free DHEA. DHEA-S cannot converted by the body into free DHEA. DHEA can be converted into DHEA-S, but not the other way around. There is an excellent medical research study that proves this.

(Hammer, Fabian, Subtil s, Lux P, Maser-Gluth C, Stewart P, et al “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and In Vitro Studies” Journal of Endocrinology and Metabolism. March 8 2005 pp 3600-3605) http://jcem.endojournals.org/content/90/6/3600.full.pdf

#3 Medical research shows the human body metabolizes most DHEA into various smaller, more specific hormones in the skin (the dermis). The skin is where we metabolize much of the DHEA we make. So Twist 25 DHEA cream actually provides exactly what the body produces naturally, bioidentical DHEA where it can be utilized, the skin. DHEA also has many skin-care benefits because DHEA is a base for sebum, helps with collagen formation, and protects skin cells from both UV and chemical carcinogens.

“In postmenopausal women, all estrogens and most androgens are made locally in peripheral target tissues from the inactive adrenal steroid precursor dehydroepiandrosterone (DHEA). In adult men, approximately 50% of androgens are made locally.”

(Labrie F. et al Semin Reprod Med. 2004 Nov;22(4):299-309. Adrenal androgens and intracrinology.

Source: Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada. [email protected])


So instead of wasting time and money on DHEA pills that have little or no noticeable benefit, use Twist 25 DHEA cream by rubbing it into thin hairless skin where it absorbs quickly and leaves no residue or odor.

Twist 25 DHEA cream is made with a pharmaceutical-grade coconut oil base cream and also contains coenzyme Q-10 and vitamin E. It contains all plant-sourced ingredients. It has no parabens, no lecithin, no cyclodextrin.

DHEA is the same hormone precursor in men as it is in women. It is simply a base that the body uses however it needs to. Obviously, men process it into different hormones than women do.

The body uses free DHEA as a precursor to the sex hormones, whereas DHEA sulfate does not. This is why people feel and notice the benefits of using Twist 25 DHEA cream instead of pills.

Twist 25 DHEA cream does cost a bit more than DHEA pills or imitation products. This is because Twist 25 DHEA cream contains pharmaceutical-grade ingredients compounded in an FDA-approved facility into a highly specialized cream that is tested for proper mix and strength. 

Suggested use

Each full pump press from the Twist 25 pump contains 25 MG DHEA. Noticeable benefits of DHEA cream begin to be felt within a few weeks of regular daily use.

DHEA is safe, is not addictive or habit-forming and has no dangerous side effects. DHEA is the most abundant naturally occurring prohormone in the human body.

Twist 25 DHEA cream is generally recommended for men or women aged 35 and up. Twist 25 DHEA cream has not been tested for use by women who are pregnant or nursing and has no dangerous side effects.

Twist 25 DHEA cream is made and sold only in the U.S.A. No prescription is required. In some countries like Canada, France, and Australia, products containing DHEA require a physician’s prescription. Health2Go, Inc. can only accept orders from customers with a bill to address and ship to address in the U.S.A.

It is important to use Twist 25 DHEA cream properly to get the many benefits DHEA can provide.

As summarized by Dr. John Woodward, M.D. “DHEA must be used as a bioidentical DHEA cream called Twist 25. Use Twist 25 DHEA cream. Make your own hormones.”

User Testimonials

“This cream has been remarkable for me! I’m 55 and was struggling BIG TIME… with lack of well being, lack of energy and lack of labido. From the first pump, I noticed something … albeit very small.. but within 3 weeks I am a different woman! I don’t feel the need for naps, my well being restored and my labido better than ever! This product is the REAL DEAL! I’m so thankful to have found this product!🙌

Female, Age 55, Mont Vernon, New Hampshire

“DHEA is the most abundant base for hormones in our body. It is not a foreign substance. We make it and have it in our systems. So keep DHEA levels where they are when we are healthiest. It just makes sense.”
– Female, Medical Doctor, Dallas, Texas, Age 47

“I have received a wonderful blessing… Twist 25! I know some people throw around the phrase ‘blessing’, but I don’t. I finally am getting my life back. Here is a list of some of the great changes I have experienced so far: energy & depth, Results when I work out, Faster recovery after workouts, Feeling of “centeredness” or “well-being” in everyday life, soft hydrated skin, healthy hair, fast-growing fingernails, mental clarity, consistent sex drive, sound sleep

I‘ve been using Twist 25 for 5 years. I look forward to getting up every day, working out, and living a happier, healthier life!”

– Female, Julie W., Demoines, Iowa, Age 42

“I started using Twist 25 about 6 months ago, and it’s great. I started on a new health kick. Seems like I’m making more of life. I feel great… About 3 weeks after I started using Twist, I started exercising more and going to the gym ‘ I had a drive to do it – I worked out with my weights some, jogged a few times more than I usually do, and …..that’s it. I feel great. I’m productive at work. I sleep better at night. Twist 25 helps me thrive. It keeps me at my best.”
– Male, Age 43

“I have been using DHEA cream for 4 years and believe it has had an impact on the overall condition of my body at this age. I work out 4 times per week now. No one in the gym can believe I just turned 55 (she laughs). I have less than 10% body fat, and my muscles are defined…see (laughing)..and this guy at the gym told me I have the body of a 30-year-old.”(deep smile)
– Female, Marketing Consultant, Age 56

“I have been using Twist 25 for 4 years. I feel great. I have more energy, and my skin is softer. I feel fit and trim and don’t have to work out as much as I used to to stay in shape. I recover faster after my workouts and benefit more. I have more energy, and I’m leaner. It’s amazing. I love it!”
– Female, Designer and Fashion Model, Age 49

“I’m 72 years old and have been taking DHEA for eleven years. My wife has been using DHEA for 18 years. We don’t take it for any major effect. It’s lots of subtle effects, not dramatic… DHEA is basic. The question is not whether we are going to live longer from DHEA supplementation. The question is: Will we live in a youthful state day to day? DHEA helps us maintain a higher quality life.”
– William Regelson, M.D. professor of medicine at the Medical College of Virginia

How to begin to use Twist 25 DHEA cream

As explained above, to benefit from DHEA supplementation and actually feel the benefits, it is crucial to use DHEA the right way, as an absorbable skin cream. To begin using Twist 25 DHEA cream, stop using DHEA pills. Twist 25 DHEA cream is available to buy online as well as from many health care providers and health supplement retailers in the USA. Twist 25 DHEA cream is a bit more expensive than oral DHEA supplement pills. This is because Twist 25 DHEA cream is made with top quality pharmaceutical grade ingredients in a facility following good manufacturing practices, GMP, and following all requirements of the FDA. Twist 25 DHEA cream is laboratory tested to meet microanalysis standards and proper mix. Don’t be fooled by cheap imitation products.

Apply one or two pump presses of Twist 25 DHEA cream onto thin hairless skin and rub in until the cream absorbs completely. Each full pump press from the pump bottle contains 25 MG pharmaceutical grade bioidentical DHEA.

Make it part of your daily routine. Twist 25 DHEA cream should be applied morning and evening every day. Twist 25 DHEA cream is for external use.

It’s a good thing to apply after a warm bath or shower when the skin is clean and dry; skin pores are open and clean, and blood flow is good. Avoid sensitive skin near the eyes or mouth.

FAQs: Common Questions about DHEA and Twist 25 DHEA cream

Do men and women have different DHEA?
No. The DHEA molecule itself is the same for men as for women. Men and women both produce the exact same molecule known as DHEA; but men typically make a bit more than women do. Women’s levels peak at about 350-400; while for men, levels peak at between 350-650. Here are the typical “normal” levels throughout life for men and women at different ages.

Can I use Twist 25 DHEA cream if I am taking medications? Yes. DHEA, dehydroepiandrosterone, is not a foreign substance. It not a medication or drug. It is the most abundant naturally occurring prohormone in the human body. DHEA is available over the counter (OTC) without a prescription. Health2Go recommends that you tell your physician you are using Twist 25 DHEA cream.

How long does a bottle of Twist 25 DHEA cream last? One container of Twist 25 cream contains 50 ml of cream. Each full pump press releases 0.5 ml of cream. It is a good idea to give the pump a firm thump with the cap on it on a countertop or table to make sure air is cleared from the actuator head and prime the pump before each use. There are about 90 squirts of cream in a bottle. So, if one pump press is applied each morning and evening, then one container of cream will last about 45 days.

If I use Twist 25 DHEA cream will it cause me to make less of my own DHEA? Do I need to take breaks or holidays from using Twist 25 DHEA cream? No. DHEA is not addictive or habit forming. When you use DHEA cream it does not cause your body to make less of it’s own DHEA. Therefore, if you choose to discontinue use, you will go right back to producing you do naturally. No problem at all. So there is no reason to take breaks or holidays from using the cream daily. There are no dangerous side effects from using DHEA.

Conclusion: Making the right choice with Twist 25 DHEA cream

DHEA must be used the right way to provide the many health benefits it can provide. It should be used as a properly made absorbable skin cream to work. Twist 25 DHEA cream is generally recommended for men and women aged 35 and up. Twist 25 DHEA cream has no dangerous side effects.

Use Twist 25 DHEA cream to maintain hormone balance to feel your best and look your best. As the inventor of Twist 25 DHEA cream, Dr. John Woodward, M.D., said, “DHEA must be used as a bioidentical DHEA cream called Twist 25. Use Twist 25 DHEA cream. Make your own hormones.”


Hugh R. Woodward, MHA

Hugh Woodward is President/CEO of Health2Go, Inc. Health2Go makes and sells Twist 25 DHEA cream.
Hugh has a BBA in Business Management from University of Texas in Austin, Texas and an MHA, Master of Science in Health Care Administration.

Hugh is a subject matter expert on DHEA dedicating the past 20+ years of his life to studying the medical research about it. Hugh started Health2Go, Inc. in 2007 to research and develop the safest most effective DHEA supplement cream that can be made.

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