Man working out enjoying the benefits of Twist 25 DHEA cream

DHEA for Muscle: Build Lean Muscle with Twist 25 Cream

Despite what many supplement companies would like you to believe, there is no “magic pill” out there to make you lose all the fat and gain lean shapely muscle overnight. For starters: 

  • Eat a healthy diet with a variety of fruits and vegetables.
  • Make exercise part of every day.
  • Drink water.
  • Get at least 7-8 hours of sleep.

There is sound basic science showing why DHEA cream can help. More efficient energy metabolism, burning glucose instead of storing it away as fat yields lean muscle. DHEA also helps muscle recovery, and is a base for androgenic and estrogenic hormones.  So DHEA helps support lean shapely muscle tone and faster recovery after workouts, plus it gives you the motivation, energy and drive to get out there and go.

Understanding DHEA

Dehydroepiandrosterone, or DHEA, is a naturally occurring prohormone produced in the adrenal glands, gonads and skin. DHEA is the most abundant prohormone in the human body. DHEA is the base building block, “the mother hormone” for smaller more specific carbon chain molecule hormones like estrogen and testosterone.

The Role of Hormones in Lean Muscle and Recovery

The body makes all sex hormones 50 other hormones from DHEA. Hormones drive our energy, mood, muscle tone, fat, quality of sleep, mental sharpness, immune system, sex drive, cardiovascular health and more.

People gradually make more and more DHEA from birth through puberty into adulthood until about age 25, when we are “in our reproductive prime” as humans, at our best. Then after age 25, DHEA levels decline at a rate of about 2% per year. 

So, by age 35 men and women alike are making about 20% less than they did when they were fittest; and by 50 we are making about half as much as when we were in our prime. Other factors, including alcohol and caffeine consumption, and stress, can also accelerate the decline of DHEA levels.

Optimal DHEA Supplementation: The Importance of Skin Absorption

Since DHEA is a precursor to hormones including testosterone, estrogen and about 50 other hormones, it is often used as a health supplement to help support overall health and well-being. 

What most people don’t know though, is that DHEA must be used as a properly made absorbable DHEA skin cream to work – not as an oral supplement in order for it function as a base, precursor for the androgenic and estrogenic sex hormones. The liver filters out oral DHEA supplements  before they can do any good, and only increases the level of DHEA sulfate – not free DHEA. Free DHEA is what the body uses to make sex hormones. 

 The method of use of DHEA is key to the results that may be gained from using it. It is crucial to supplement DHEA the right way. DHEA supplementation works best when absorbed in the skin using a properly made cream. Dr. Fernand Labrie, of the University of Toronto Medical School has researched and published a number of medical studies showing this. 

Science Behind DHEA Metabolism in the Dermis

 A great deal of hormone metabolism that goes on in the skin, or dermis. So, it makes sense to supplement DHEA with what the body makes and uses naturally, bioidentical DHEA; and apply and absorb the DHEA where the body makes and uses DHEA naturally, the skin.

Hormones are the chemical messengers that drive us. How we feel. How we function. How we look. They are the conductors of the great harmony we call the human body. Testosterone in males drives muscular development and larger body size. Estrogenic hormones in women likewise, yield the smoother  muscle shape that gives women their characteristic body shape and smooth skin, for example.

In the presence of DHEA, cells grow and build. In the absence of DHEA cells fall apart when they die in a process called apoptosis. Science has shown that when DHEA levels are higher, epithelial cells, neuronal cells, osteocytes and cartilage regenerate better. 

DHEA also has been shown to improve nitric oxide production which is known to play an important role in vascular function to develop healthy lean muscle. DHEA helps the body to form epithelial cells. DHEA also counterbalances the detrimental effects inflammatory effects of cortisol in muscles and fat tissue.

Benefits of Using DHEA for Lean Muscle

  • Enhances Immune System Function
  • Increases Energy Levels And Drive
  • Aids In Cell Reproduction
  • Inhibits Cellular Apoptosis
  • Base For Production Of Sex Hormones Like Testosterone And Estrogen
  • Helps Reduce Fat
  • Supports The Development Of Lean Muscle Mass
  • Speeds Muscular Recovery
  • Improved Cardiovascular Health
  • Deeper REM Sleep

Because DHEA counterbalances many of the harmful inflammatory effects of cortisol, and supports cell growth and vascular health, DHEA greatly reduces the recovery time needed after workouts so you can train harder and more frequently. Meanwhile, DHEA is also supporting the immune system, cardiovascular health, enhancing mood and mental sharpness, and making skin softer too. DHEA is a naturally occurring prohormone so DHEA has no dangerous side effects.

Guidelines for Effective DHEA Cream Application & Lifestyle Tips

As shown in the graph, DHEA levels gradually decrease after age 25, so older women and men over age 35 should apply DHEA cream morning and evening every day. Make Twist 25 DHEA cream part of your daily routine. Each full pump press contains 25 MG DHEA that should be rubbed into thin hairless skin morning and evening each day.

The most important thing to remember: Is that DHEA must be used as a properly made bioidentical DHEA cream – not as an oral supplement. Oral DHEA supplements are mostly destroyed by the liver before they can do any good, and only increase the level of DHEA sulfate – not free DHEA, free DHEA is what the body uses to make sex hormones. Sex hormones are what allow muscle tone and drive how we feel and function.

So eat a healthy diet, drink plenty of water, get enough sleep, and get out there and exercise every day!

Use Twist 25 DHEA cream – Make your own hormones.


  • Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. Nov 10 2004; 292(18): 2243-8.
  • Tivesten Asa, LiesbethVandenput, Daniel Carlzon, et al. Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men. Journal of the America College of Cardiology. October 28 2014, Volume 64, pages 1801-1810.
  • DHEA Improves Mental Function and Combats Depression Life Enhancement magazine.
  • Villareal DT, Holloszy JO, Kohrt. WM Effects of DHEA on bone mineral density and body composition in elderly women and men. Clinical Endocrinology Oxford November 2005 53(5): 561-8
  • Fernand Labrie DHEA and intracrinology at menopause, a positive choice for evolution of the human species. Climacteric. 2013 Apr;16(2):205-13.
  • E Friess, Trachsel L, Guldner J, Schier T, et al. DHEA administration increase rapid eye movement sleep and EEG power in the sigma frequency range. American Journal of Physiology. January 1995. Pages 107-13.

Hugh R. Woodward, MHA

Hugh Woodward is President/CEO of Health2Go, Inc. Health2Go makes and sells Twist 25 DHEA cream.
Hugh has a BBA in Business Management from University of Texas in Austin, Texas and an MHA, Master of Science in Health Care Administration.

Hugh is a subject matter expert on DHEA dedicating the past 20+ years of his life to studying the medical research about it. Hugh started Health2Go, Inc. in 2007 to research and develop the safest most effective DHEA supplement cream that can be made.

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