Naturally Improve Heart Health & Reduce Heart Disease Risk

Naturally Improve Heart Health & Reduce Risk Factors with DHEA

Improve Heart Health with DHEA the right way

Heart disease is the leading cause of death in the United States and currently accounts for about one in four (25%) deaths each year. About 700,000 people in the United States died from heart disease in 2021; and the numbers have been increasing in 2022 (875,000 deaths) and 2023. It is estimated that 80% of these cases could have been prevented by controlling the risk factors.

Explore the many benefits of DHEA to help improve heart health to better understand how this important prohormone may offer a protective effect against cardiovascular disease.

“Heart disease” refers to several heart conditions, with the most common being coronary artery disease (CAD), which affects blood flow to the heart.  Some of the risk factors of heart disease are chronic stress, high blood pressure, high cholesterol, diabetes, obesity, bad diet, lack of physical activity, and alcohol abuse.

Unfortunately, as we age, we become more susceptible to these risk factors and need to focus on living a healthier lifestyle. If you want to curb your risk of heart disease, then you need to eat a heart-healthy diet full of leafy greens and whole foods, get regular cardiovascular exercise, avoid smoking, and consume alcohol in moderation.

While changing your lifestyle may be easier said than done, dehydroepiandrosterone (DHEA) can help boost your energy levels and also have physiological effects that improve heart health. Twist 25 DHEA cream is a great way to supplement DHEA to get positive results to help stave off heart disease.

What Is DHEA? Understanding the hormone

DHEA is the most abundant naturally occurring hormone precursor in the human body. It is a base building block for hormones and counterbalances cortisol, the stress hormone. From birth, humans naturally produce more and more DHEA until about age 25, when we are in our reproductive prime. Then we begin to produce about 2% less each year thereafter.

So, by age 35 men and women alike produce about 20% less DHEA than when they were at their physical prime (age 20-25); and by age 50, produce only about half as much DHEA as when in our twenties. This gradual decline continues. Meanwhile, levels of cortisol gradually increase throughout our lives.

dhea for heart health chart

Improve Heart Health With DHEA

Medical Research shows significant positive impacts on heart health

According to research, as DHEA levels rise, the risk of heart failure declines. Lower levels of DHEA are associated with a greater risk of cardiovascular disease. Studies suggest that DHEA delays the onset of CAD (Coronary Artery Disease) and may benefit the entire cardiovascular system.

A study from Drs. Claes Ohlsson and Fernand Labrie found that lower DHEA levels were correlated to higher rates of death from heart disease. Another study presented at The Endocrine Society’s annual meeting showed that low levels of DHEA are associated with an increased risk of heart and blood-vessel disease in men. In this medical research study, men with low DHEA levels were significantly more likely than those with higher DHEA levels to develop cardiovascular disease within five years.

DHEA’s effects on blood vessels and the cardiovascular system

Research conducted in 2012 and published on PubMed shows that DHEA supplementation slows down changes in the heart, i.e., the cardiac remodeling that occurs with the aging process. The medical research also found that DHEA helps to reduce blood vessel wall tension because of its vasorelaxant properties. DHEA must be delivered to the body properly as a DHEA cream.

In two separate clinical studies, researchers found a significant difference in the health of epithelial cells, which are the cells that line the blood vessels. Epithelial cells allow for the elasticity of blood vessels, determining how well veins and arteries dilate and contract as blood is pumped through the body.

The way our blood vessels contract and dilate is measured as blood pressure and is a strong predictor of future heart disease and cardiovascular problems. The study found that for people who supplemented DHEA on a daily basis, arterial dilation greatly improved during the course of the study.

The role of DHEA in preventing blood clots

Additionally, the studies showed that DHEA inhibited the formation of blood clots by preventing the body from releasing a protein called PAI-1, or plasminogen activator inhibitor type 1, which interferes with the body’s ability to dissolve the tiny blood clots that spontaneously form in our bloodstream. By reducing the release of PAI-1, DHEA can help the body dissolve these tiny blood clots before they become bigger, more serious or potentially fatal blood clots.

How To use DHEA to improve Heart Health

Medical research shows the human body metabolizes DHEA into other hormones in the skin, the dermis. A great deal of hormone metabolism occurs in the skin. So Twist 25 DHEA cream actually provides something the body produces and uses naturally, bioidentical DHEA, in the skin where it is used naturally. 

DHEA should be used as an absorbable skin cream rather than a pill to work best because oral DHEA supplements ingested through the gut as a pill are eliminated by the first-pass effect of the liver. The liver eliminates most DHEA before it can do any good. Twist 25 DHEA cream is DHEA the right way.

Twist 25 can not only help reduce risks of heart disease, it actually helps with energy, mood and muscle tone which are things we can feel. Staying physically active is one of the most important lifestyle factors that can help maintain a healthy cardiovascular system. There are many other physiological and psychological anti-aging effects of DHEA to help us feel and function better.

Frequently asked questions about DHEA and Heart Disease

Many people ask whether DHEA will raise their blood pressure. The answer is: No, DHEA, dehydroepiandrosterone, actually helps to lower blood pressure by relaxing the walls of veins and arteries and helping with epithelial cell formation, which are the cells that line veins and arteries throughout the body.

Do men and women have different DHEA?
No. The DHEA molecule itself is the same for men as for women. Men and women both produce the exact same molecule known as DHEA; but men typically make a bit more than women do. Women’s levels peak at about 350-400; while for men, levels peak at between 350-650. Here are the typical “normal” levels throughout life for men and women at different ages.

Can I use Twist 25 DHEA cream if I am taking medications? Yes. DHEA, dehydroepiandrosterone, is not a foreign substance. It not a medication or drug. It is the most abundant naturally occurring prohormone in the human body. DHEA is available over the counter (OTC) without a prescription. Health2Go recommends that you tell your physician you are using Twist 25 DHEA cream.

Will taking DHEA increase risks of cancer? No. Medical research studies have not found any increased risk of developing cancer from DHEA. In fact, research findings have shown that DHEA helps support the immune system by helping to boost the number of and activity of NK (natural killer) cells that help the body to destroy foreign pathogens and mutant cells.

How long does a bottle of Twist 25 DHEA cream last? One container of Twist 25 cream contains 50 ml of cream. Each full pump press releases 0.5 ml of cream. It is a good idea to give the pump a firm thump with the cap on it on a countertop or table to make sure air is cleared from the actuator head and prime the pump before each use. There are about 90 squirts of cream in a bottle. So, if one pump press is applied each morning and evening, then one container of cream will last about 45 days.

If I use Twist 25 DHEA cream will it cause me to make less of my own DHEA? Do I need to take breaks or holidays from using Twist 25 DHEA cream? No. DHEA is not addictive or habit forming. When you use DHEA cream it does not cause your body to make less of it’s own DHEA. Therefore, if you choose to discontinue use, you will go right back to producing you do naturally. No problem at all. So there is no reason to take breaks or holidays from using the cream daily. There are no dangerous side effects from using DHEA.

User Testimonials

“This cream has been remarkable for me! I’m 55 and was struggling BIG TIME… with lack of well being, lack of energy and lack of labido. From the first pump, I noticed something … albeit very small.. but within 3 weeks I am a different woman! I don’t feel the need for naps, my well being restored and my labido better than ever! This product is the REAL DEAL! I’m so thankful to have found this product!🙌

Female, Age 56, Mont Vernon, New Hampshire

“DHEA is the most abundant base for hormones in our body. It is not a foreign substance. We make it and have it in our systems. So keep DHEA levels where they are when we are healthiest. It just makes sense.”
– Female, Age 47, Medical Doctor, Dallas, Texas,

“I have received a wonderful blessing… Twist 25! I know some people throw around the phrase ‘blessing’, but I don’t. I finally am getting my life back. Here is a list of some of the great changes I have experienced so far: energy & depth, Results when I work out, Faster recovery after workouts, Feeling of “centeredness” or “well-being” in everyday life, soft hydrated skin, healthy hair, fast-growing fingernails, mental clarity, consistent sex drive, sound sleep

I‘ve been using Twist 25 for 5 years. I look forward to getting up every day, working out, and living a happier, healthier life!”

– Female, Julie W., Age 42, Demoines, Iowa,

“I started using Twist 25 about 6 months ago, and it’s great. I started on a new health kick. Seems like I’m making more of life. I feel great… About 3 weeks after I started using Twist, I started exercising more and going to the gym ‘ I had a drive to do it – I worked out with my weights some, jogged a few times more than I usually do, and …..that’s it. I feel great. I’m productive at work. I sleep better at night. Twist 25 helps me thrive. It keeps me at my best.”
– Male, Age 43, Dallas, Texas

“I have been using DHEA cream for 4 years and believe it has had an impact on the overall condition of my body at this age. I work out 4 times per week now. No one in the gym can believe I just turned 55 (she laughs). I have less than 10% body fat, and my muscles are defined…see (laughing)..and this guy at the gym told me I have the body of a 30-year-old.”(deep smile)
– Female, Age 56, Marketing Consultant

“I have been using Twist 25 for 4 years. I feel great. I have more energy, and my skin is softer. I feel fit and trim and don’t have to work out as much as I used to to stay in shape. I recover faster after my workouts and benefit more. I have more energy, and I’m leaner. It’s amazing. I love it!”
– Female, Designer and Fashion Model, Age 49

“I’m 72 years old and have been taking DHEA for eleven years. My wife has been using DHEA for 18 years. We don’t take it for any major effect. It’s lots of subtle effects, not dramatic… DHEA is basic. The question is not whether we are going to live longer from DHEA supplementation. The question is: Will we live in a youthful state day to day? DHEA helps us maintain a higher quality life.”
– William Regelson, M.D. professor of medicine at the Medical College of Virginia

So if you are 35 and up, male or female, and want to reduce your risks for developing cardiovascular disease and improve your heart health, using Twist 25 DHEA cream makes sense. Apply one or two pump presses morning and evening every day. Get at least 30 minutes of moderate physical exercise at least 4 days a week, and eat a healthy diet low in saturated fat and high in vegetables. Naturally maintain youthful vigor and health with Twist 25 DHEA cream.


  • Jean-Pierre Savineau, Roger Marthan, Eric Dumas de la Roque. “Role of DHEA in cardiovascular diseases”. Biochemical Pharmacology. Mar 15 2013; 85(6):718-26.doi: 10.1016/j.bcp.2012.12.004. Epub 2012 Dec 25.
  • Claes Ohlsson, MD, Fernand Labrie, MD, Elizabeth Barrett-Conner, MD, Magnus K Karlsson, MD, PhD, Osten Ljunggren, MD, PhD, Osten Ljunggren, MD, PhD, Liesbeth Vandenput, PharmD, PhD, Dan Mellstrom, PhD, Asa Tivesten, MD, PhD, “Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men”. Journal of Clinical Endocrinology and Metabolism. Sept 2010;95(9):4406-14. doi: 10.1210/jc.2010-0760. Epub Jul 7 2010.
  • Aaron W. Jensen, PhD. “DHEA Protects Against Against Heart Disease and Diabetes”.  Life Enhancement.
  • Asa Tivesten, MD, PhD, Liesbeth Vandenput, PharmD, PhD, Daniel Carizon, MD, Maria Nilsson, MD, Magnus K Karlsson, MD, PhD, Osten Ljunggren, MD, PhD, Elizabeth Barrett-Conner, MD, Dan Mellstrom, PhD, Claes Ohlsson, MD, PhD. “Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men”. Journal of The American College of Cardiology. Vol. 64, No 17, 2014.
  • “Low Levels of DHEA Prohormone Predict Coronary Heart Disease”. University of Gothenberg. Medical Express. November 10 2014.
  • Fernand Labrie, Labrie C, “DHEA and intracrinology at menopause, a positive choice for evolution of the human species” Source: Climcteric – The Journal of the International Menopause Society. 2013 Apr;16(2):205-13. doi: 10.3109/13697137.2012.733983. Epub 2012 Nov 5. Pubmed

Hugh R. Woodward, MHA

Hugh Woodward is President/CEO of Health2Go, Inc. Health2Go makes and sells Twist 25 DHEA cream.
Hugh has a BBA in Business Management from University of Texas in Austin, Texas and an MHA, Master of Science in Health Care Administration.

Hugh is a subject matter expert on DHEA dedicating the past 20+ years of his life to studying the medical research about it. Hugh started Health2Go, Inc. in 2007 to research and develop the safest most effective DHEA supplement cream that can be made.

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