DHEA and Cardiovascular Health: Enhancing Heart Health and Reducing Risks of Heart Disease

Boost Your Heart Health with DHEA cream

Heart disease holds the grim title of being the leading cause of death in the United States, tragically accounting for about one in every four (25%) deaths yearly. The statistics are alarming, with over a million people succumbing to heart disease in 2023, up from 700,000 in 2021 and 875,000 in 2022. Yet, there are many things we can do to avoid problems with heart health. Experts estimate that 80% of these cases could have been prevented by managing known risk factors. Discover how using DHEA for cardiovascular health might make a significant difference.

Medical research now provides scientific findings of many benefits of DHEA to help improve cardiovascular health. Science is allowing us to better understand how an important pro-hormone, DHEA, can provide protective effects to avoid cardiovascular disease by reducing inflammation and allowing healthier epithelial cell formation to help with vascular health and elasticity to keep blood pressure in the normal range.

“Heart disease” encompasses a variety of heart conditions, with coronary artery disease (CAD) being the most prevalent. CAD specifically impairs blood flow to the heart. Several risk factors contribute to heart disease, including chronic stress, high blood pressure, high cholesterol, diabetes, obesity, poor diet, lack of physical activity, smoking, and alcohol consumption.

As we grow older, our vulnerability to these risk factors increases, making it essential to prioritize a healthier lifestyle. To effectively reduce the risks of heart disease, focus on eating a heart-healthy diet rich in leafy greens, engaging in regular cardiovascular exercise, avoiding smoking, and consuming alcohol in moderation.

While changing lifestyle habits can be challenging, dehydroepiandrosterone (DHEA) can help boost your energy levels and offer physiological benefits that enhance heart health. Twist 25 DHEA cream is an effective way to supplement DHEA, providing DHEA in an absorbable skin cream to help reduce risks of heart disease.

Understanding DHEA

DHEA, or dehydroepiandrosterone, stands as the most abundant hormone precursor naturally found in our bodies. It acts as a foundational building block for other hormones and serves to balance out cortisol, commonly known as the stress hormone. Our bodies ramp up DHEA production from birth, peaking around age 25 when we reach our reproductive prime. However, from that point on, DHEA levels start to taper off, decreasing by about 2% each year.

By the time you reach 35, both men and women produce around 20% less DHEA compared to their peak physical years (ages 20-25). When you hit 50, your DHEA production drops to about half of what it was in your twenties. This decline is gradual but continuous.

The dark blue line in the graph below shows DHEA levels over the human lifespan. The pink line shows how we should try to reduce that gradual decline to reduce the risks of cardiovascular disease and other physiological and psychological health declines as we get older. Maintaining healthier DHEA levels has many benefits and no dangerous side effects.

dhea for heart health chart

As we age, cortisol levels tend to steadily rise over time.

Enhance Your Heart Health Using DHEA

Medical Research shows DHEA has significant positive effects on cardiovascular health

According to research, as DHEA levels increase, the risk of heart failure decreases. Lower DHEA levels are linked to a heightened risk of cardiovascular disease. Medical studies indicate that boosting DHEA might delay the onset of CAD (Coronary Artery Disease) and could provide significant benefits to the entire cardiovascular system.

A study conducted by doctors Claes Ohlsson and Fernand Labrie revealed a stark correlation between lower DHEA levels and increased mortality rates from heart disease. Additionally, a compelling study showcased at The Endocrine Society’s annual meeting found that low DHEA levels are linked to a heightened risk of cardiovascular disease in men. Specifically, the research underscored that men with lower DHEA levels were significantly more likely to develop cardiovascular disease within a five-year span compared to those with higher levels.

DHEA’s effects on blood vessels and the cardiovascular system

Medical research from 2012 published on PubMed reveals that DHEA supplementation significantly slows age-related cardiac remodeling. This study also highlights how DHEA reduces blood vessel tension, thanks to its vasorelaxant properties. For optimal benefits, it’s crucial to deliver DHEA to the body using a DHEA cream.

In two separate clinical studies, researchers discovered a notable improvement in the health of epithelial cells, the cells lining your blood vessels. These cells are crucial for maintaining the elasticity of your blood vessels, which determines how effectively your veins and arteries expand and contract as blood circulates through your body.

Blood pressure, a key indicator of how our blood vessels contract and dilate, strongly predicts future heart disease and cardiovascular issues. Research reveals that daily DHEA supplementation significantly enhances arterial dilation over time.

The role of DHEA in preventing blood clots

Furthermore, studies have revealed that DHEA effectively inhibits blood clot formation. It does this by reducing the release of a protein known as PAI-1 (plasminogen activator inhibitor type 1), which can interfere with the body’s natural ability to dissolve small, spontaneous blood clots in the bloodstream. By lowering PAI-1 levels, DHEA helps the body to break down these minor clots before they become larger, more dangerous, or even life-threatening.

DHEA also supports better metabolic health and losing weight

Medical research performed by Dr. Dennis T. Villareal, M.D. and Dr. John O. Holloszy, M.D. showed that “DHEA replacement could play a role in prevention and treatment of the metabolic syndrome associated with abdominal obesity.” The science is believed to be because higher DHEA levels allows for glucose to be more efficiently burned as energy rather than being stored away as fat.

How To use DHEA for cardiovascular health

Medical research shows that DHEA is metabolized into other hormones right in the skin, specifically in the dermis. This is where much of your body’s hormone metabolism takes place. Using Twist 25 DHEA cream offers a natural and bioidentical form of DHEA, delivered precisely where your body uses it most—your skin.

For optimal results, DHEA should be applied as an absorbable skin cream rather than taken in pill form. When ingested orally, DHEA undergoes the first-pass effect through the liver, which eliminates most of the hormone before it can take effect. That’s why using a DHEA cream like Twist 25 is the right approach to enhance its benefits.

Twist 25 does more than just reduce the risk of heart disease; it boosts energy levels, improves mood, and enhances muscle tone. Staying active is crucial for a healthy cardiovascular system, and DHEA can help with that. The physiological and psychological anti-aging benefits of DHEA contribute to a better overall quality of life.

Frequently asked questions about DHEA and Cardiovascular Health

Curious about whether DHEA might increase your blood pressure? Good news! DHEA, or dehydroepiandrosterone, actually works to lower blood pressure. It achieves this by relaxing the walls of your veins and arteries, as well as aiding in the formation of epithelial cells, which line these blood vessels throughout your body.

Can I use Twist 25 DHEA cream if I am taking medications?

Absolutely. DHEA, or dehydroepiandrosterone, is not an alien substance; it’s a naturally occurring prohormone produced abundantly in the human body. Unlike medications or drugs, DHEA is available over the counter (OTC) without needing a prescription. However, Health2Go advises you to inform your physician that you are using Twist 25 DHEA cream to ensure it fits well with your overall health regimen.

Will taking DHEA increase the risks of cancer? No, it won’t. Medical research indicates no link between DHEA and a heightened cancer risk. Actually, DHEA supports your immune system by increasing both the number and activity of NK (natural killer) cells, which are vital for destroying harmful pathogens and abnormal cells.

The Bottom Line on DHEA and Cardiovascular Health

So, if you are 35 or older, male or female, and want to reduce your risks for developing cardiovascular disease and improve your heart health with no dangerous side effects, using Twist 25 DHEA cream as part of your daily routine makes sense.

The medical research has shown us that DHEA helps to reduce inflammation and helps support the cells that line the veins and arteries thoughout the cardiovascular system. DHEA also reduces fat accumulation by supporting a healthier metabolism, and gives us more energy and drive to be more active and exercise.

Using Twist 25 DHEA cream is straightforward. Apply one or two pumps, both morning and evening, daily. Ensure you get at least 30 minutes of moderate physical exercise at least four days a week, and stick to a healthy diet that’s low in saturated fats but rich in vegetables. Keep your youthful energy and support cardiovascular health naturally with Twist 25 DHEA cream.


  • Jean-Pierre Savineau, Roger Marthan, Eric Dumas de la Roque. “Role of DHEA in cardiovascular diseases”. Biochemical Pharmacology. Mar 15 2013; 85(6):718-26.doi: 10.1016/j.bcp.2012.12.004. Epub 2012 Dec 25. https://pubmed.ncbi.nlm.nih.gov/23270992/
  • Claes Ohlsson, MD, Fernand Labrie, MD, Elizabeth Barrett-Conner, MD, Magnus K Karlsson, MD, PhD, Osten Ljunggren, MD, PhD, Osten Ljunggren, MD, PhD, Liesbeth Vandenput, PharmD, PhD, Dan Mellstrom, PhD, Asa Tivesten, MD, PhD, “Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men”. Journal of Clinical Endocrinology and Metabolism. Sept 2010;95(9):4406-14. doi: 10.1210/jc.2010-0760. Epub Jul 7 2010. https://pubmed.ncbi.nlm.nih.gov/20610590/
  • Aaron W. Jensen, PhD. “DHEA Protects Against Against Heart Disease and Diabetes”.  Life Enhancement. https://www.life-enhancement.com/magazine/article/875-dhea-protects-against-heart-disease-and-diabetes
  • Asa Tivesten, MD, PhD, Liesbeth Vandenput, PharmD, PhD, Daniel Carizon, MD, Maria Nilsson, MD, Magnus K Karlsson, MD, PhD, Osten Ljunggren, MD, PhD, Elizabeth Barrett-Conner, MD, Dan Mellstrom, PhD, Claes Ohlsson, MD, PhD. “Dehydroepiandrosterone and its Sulfate Predict the 5-Year Risk of Coronary Heart Disease Events in Elderly Men”. Journal of The American College of Cardiology. Vol. 64, No 17, 2014. https://www.sciencedirect.com/science/article/pii/S0735109714059403
  • “Low Levels of DHEA Prohormone Predict Coronary Heart Disease”. University of Gothenberg. Medical Express. November 10 2014. https://medicalxpress.com/news/2014-11-dhea-prohormone-coronary-heart-disease.html
  • Fernand Labrie, Labrie C, “DHEA and intracrinology at menopause, a positive choice for evolution of the human species” Source: Climeteric – The Journal of the International Menopause Society. 2013 Apr;16(2):205-13. doi: 10.3109/13697137.2012.733983. Epub 2012 Nov 5. Pubmed https://pubmed.ncbi.nlm.nih.gov/23126249/
  • Dennis T. Villareal, M.D., Dr. John O. Holloszy, M.D. “Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men – A Randomized Controlled Trial”. JAMA – Journal of American Medical Association. Nov 10, 2004. JAMA. 2004;292(18):2243-2248. doi:10.1001/jama.292.18.2243 https://jamanetwork.com/journals/jama/fullarticle/199765

Hugh R. Woodward, MHA

Hugh Woodward is President/CEO of Health2Go, Inc. Health2Go makes and sells Twist 25 DHEA cream.
Hugh has a BBA in Business Management from University of Texas in Austin, Texas and an MHA, Master of Science in Health Care Administration.

Hugh is a subject matter expert on DHEA dedicating the past 20+ years of his life to studying the medical research about it. Hugh started Health2Go, Inc. in 2007 to research and develop the safest most effective DHEA supplement cream that can be made.

View profile

Leave a Comment

Your email address will not be published. Required fields are marked *

Shopping Cart