DHEA Cream vs Pills: Why use DHEA as a cream?

DHEA, an abbreviation for dehydroepiandrosterone, stands as the most abundant naturally occurring pro-hormone within the human body. Not an alien substance but rather a native hormone precursor, DHEA is unique to humans. In this piece, we discuss the core distinctions between DHEA cream vs pills, highlighting why an absorbable cream supplement offers superior effectiveness and safety. It’s tailored to work harmoniously with where and how the body naturally utilizes it. 

For those aged 35 and older, the Twist 25 DHEA supplement cream emerges as the optimal choice to sustain balanced hormones and reap the myriad of health and psychological benefits that DHEA endows.

Discovered by Dr. Adolf Butenandt in 1931, who subsequently received the Nobel Prize for Chemistry in 1939, DHEA has earned the nickname “the anti-aging hormone.” Recognized as the precursor to over 50 hormones, DHEA comprises smaller or more specialized carbon chain molecules within our body’s complex biochemistry. From the moment we are born, our bodies naturally produce DHEA, the foundational element for all estrogenic and androgenic hormones. 

As the body’s most abundant base for hormone synthesis, DHEA is both produced and metabolized in the adrenal glands, gonads, and dermis. This metabolic versatility is a compelling reason why applying DHEA through a skin cream can be more effective than ingesting DHEA in pill form.

Understanding the rationale behind choosing an absorbable DHEA skin cream over a pill is essential. Crafted with a specialized coconut oil base, this cream ensures effective absorption. Let’s dive into the science behind it.

DHEA levels over the human lifespan

DHEA levels steadily rise from birth through adolescence and into early adulthood. They peak between the ages of 20 to 25, our so-called ‘prime years. However, following this peak, DHEA levels begin a slow, inexorable decline, diminishing by roughly 2% each year. By the time we hit 35, our bodies produce about 20% less DHEA than we did at 25. Fast forward to age 50, and that reduction reaches a staggering 50%, compared to our youthful twenties. This decline doesn’t stop there; it continues as we grow older.

 

 

 

 

 

 

 

 

 

 

Both men and women see their DHEA production ramp up significantly until it reaches a pinnacle around the age of 25. Post this peak, we start experiencing a gradual decline in DHEA levels, losing about two percent each year from that point forward.

What does DHEA do?

One of the fundamental roles of DHEA is functioning as a precursor hormone. DHEA also bolsters the immune system by enhancing both the quantity and activity of natural killer (NK) cells. It is noteworthy that low levels of DHEA are linked to numerous age-related diseases, including cardiovascular disease, cancer, osteoporosis, depression, and dementia. 

DHEA plays a vital role in tissue regeneration following exercise and counteracts the inflammatory effects of cortisol. This means it can help reduce post-workout soreness and support the rebuilding of muscle, cartilage, and bone. Additionally, DHEA is essential for producing sebum (skin oil), which protects skin cells from UV rays and chemical carcinogens. Beyond this, DHEA encourages the formation of connective tissue and cartilage, significantly improving bone strength.

How DHEA Supports Your Well-being:

• Boosts energy, enhances focus, and sharpens mental acuity
• Fortifies the immune system
• Promotes lean muscle tone
• Strengthens bones
• Supports cardiovascular health
• Enhances libido and sexual performance
• Improves deep REM sleep
• Promotes softer, more hydrated skin

The Benefits of DHEA: What It Reduces:

• Decreases abdominal fat
• Reduces the risk of cancer
• Lowers the risk of cardiovascular disease
• Combats fatigue
• Eases symptoms of depression
• Enhances sleep quality
• Soothes joint pain
• Reduces muscle soreness

There are no specific foods that can boost DHEA levels naturally. Instead, DHEA supplements are often recommended for individuals aged 35 and above to support overall health and wellness. Learn more here. 

Curious about why DHEA Cream might be a vital part of your health strategy? Our podcast delves into the essentials of DHEA and the benefits of using an effective, absorbable skin cream like Twist 25. We discuss how it supports cardiovascular health, enhances immune function, counters cortisol (the stress hormone), and aids in reducing fat and inflammation. This information is crucial for both men and women over 35. Tune in here.

DHEA cream vs pills: Why Twist 25 DHEA cream works

As indicated earlier, the human body metabolizes DHEA naturally within the dermis. Twist 25 cream offers bioidentical DHEA, mimicking exactly what the body uses, and delivering it where it’s needed most: the skin, our body’s largest organ. Utilizing Twist 25 cream can lead to noticeable benefits within a few weeks. On the other hand, DHEA pills are significantly less effective because the liver eliminates most of the DHEA before it can be utilized by the body.

Twist 25 DHEA Cream instead of a pill

There are three essential medical reasons for this: 

#1: The First-Pass Effect: How Oral DHEA is Metabolized by the Liver

When DHEA is taken orally as a pill, a significant portion is lost due to the “First-pass effect” of the liver. Essentially, the liver acts as a filter, removing most of the effective DHEA before it can positively impact your health. Consequently, what actually increases in your bloodstream is DHEA-S (DHEA sulfate), not the free DHEA. Free DHEA is the precursor from which sex hormones are metabolized. These androgenic and estrogenic hormones are crucial for maintaining that positive, well-being feeling we all strive for.

 

 

 

 

 

 

 

 

 

 

#2: The Distinction Between DHEA-S and Free DHEA: Why It Matters

DHEA-S is not the same as free DHEA, a distinction that’s pivotal when considering how the body utilizes these compounds. Notably, the body cannot convert DHEA-S back into free DHEA. While DHEA can be transformed into DHEA-S, the reverse conversion does not occur. This was elucidated in an exemplary medical research study, shedding light on the specifics. 

(Hammer, Fabian, Subtil S, Lux P, Maser-Gluth C, Stewart P, et al. “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and In Vitro Studies.” Journal of Endocrinology and Metabolism, March 8, 2005, pp. 3600-3605). For further reading, the study can be accessed here.

#3: The Role of DHEA in Skin Health: Topical Application for Optimal Results

Medical research indicates that the human body primarily metabolizes DHEA into several smaller, more specific hormones within the skin (the dermis). Since the skin is where much of our naturally produced DHEA is metabolized, Twist 25 DHEA cream delivers bioidentical DHEA exactly where it can be most effective—the skin. Beyond this, DHEA offers numerous skin-care benefits, serving as a base for sebum production, aiding in collagen formation, and providing protection against both UV radiation and chemical carcinogens.

Dr. Fernand Labrie and his team at the University of Toronto School of Medicine pioneered the discovery and naming of a novel field of medicine known as “intracrinology.” Intracrinology focuses on the intracellular functions, regulation, trafficking, and interactions of extracellular signaling peptides and proteins, including DHEA. According to Dr. Labrie’s research, in postmenopausal women, all estrogens and the majority of androgens are synthesized locally in peripheral target tissues from the adrenal steroid precursor DHEA. In adult men, approximately half of their androgens are produced locally. Essentially, a significant portion of DHEA metabolism occurs within skin cells when DHEA is applied topically, as it is processed within the cells of the dermis.

(Labrie F. et al Semin Reprod Med. 2004 Nov;22(4):299-309. Adrenal androgens and intracrinology.

Source: Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada. [email protected])

Why Investing in Twist 25 DHEA Cream vs Pills is Worth Every Penny

There are compelling financial reasons why a well-crafted DHEA cream like Twist 25 outshines pills: 

#1: Twist 25 DHEA Cream: A Superior Investment for Lasting Health Benefits

While Twist 25 DHEA cream may come with a slightly higher price tag compared to a bottle of DHEA supplement pills, it delivers unrivaled value. Unlike pills, which undergo extensive processing in the liver, Twist 25 cream introduces free DHEA directly into the dermis where it serves as a precursor for essential sex hormones. This method of delivery allows you to experience the physiological benefits of DHEA within a few weeks. In essence, although the upfront cost of the cream is higher, the substantial health and quality-of-life improvements justify the investment. 

Consider the cost versus benefit of enhanced cardiovascular health versus the expense and trauma of a heart attack. Envision the savings from a bolstered immune system that minimizes the need for medications and reduces sick days. Reflect on the transformation in your quality of life from better sleep. Unlike oral pills that burden the liver, DHEA cream is applied to the skin, bypassing the liver’s first-pass metabolism and ensuring more effective absorption. The higher bioavailability of the cream means more significant physiological and psychological health improvements, which translates to reduced healthcare costs over time. 

Indeed, DHEA pills are inexpensive, but if they fail to deliver meaningful benefits, their low cost is irrelevant. The superior efficacy and bioavailability of DHEA cream offer a much better return on investment, paving the way for improved overall health and well-being.

Application

Rather than investing your time and money in DHEA pills that often fail to deliver noticeable benefits, opt for Twist 25 DHEA cream. Simply massage it into thin, hairless skin where it absorbs swiftly into the dermis, leaving no residue or odor. It’s DHEA done right. 

Twist 25 DHEA cream is crafted with a pharmaceutical-grade coconut oil base and enriched with coenzyme Q-10 and vitamin E. Boasting all plant-sourced ingredients, it contains no parabens, lecithin, or cyclodextrin. 

Notably, DHEA serves as the same hormone precursor in both men and women. It’s a versatile base that the body utilizes according to its unique needs, with men and women processing it into different hormones. 

While the body uses free DHEA as a precursor to sex hormones, DHEA sulfate does not serve this function. This distinction is why users often feel and notice the effects of Twist 25 DHEA cream more prominently than pills. 

Though Twist 25 DHEA cream is priced higher than pills or imitation products, its cost is justified. The cream contains pharmaceutical-grade ingredients, compounded in an FDA-approved facility, and is meticulously tested for proper formulation and potency.

Suggested use

Each full pump of Twist 25 delivers 25 mg of DHEA, and users often start to feel the benefits within a few weeks of consistent daily application. 

DHEA is considered safe, non-addictive, and free from dangerous side effects. As the most abundant prohormone naturally occurring in our bodies, its role in maintaining health is significant. 

Twist 25 DHEA cream is generally recommended for men and women aged 35 and over. Although it has not been tested for use by pregnant or nursing women, it remains free from dangerous side effects. 

Made and sold exclusively in the U.S.A., Twist 25 DHEA cream requires no prescription here, unlike some countries such as Canada, France, and Australia, where a physician’s prescription is necessary for DHEA products. Health2Go, Inc. accepts orders only from customers with billing and shipping addresses within the U.S.A. 

Proper use of Twist 25 DHEA cream is crucial for reaping its benefits. Consistent daily use, ideally twice a day—once in the morning and once in the evening—is recommended due to its 10-hour half-life. Applying the cream after a warm bath or shower can enhance absorption, as clean, dry skin with open pores and increased blood flow maximizes its efficacy. It’s advisable to avoid swimming or washing off the cream for at least a few hours post-application. 

As Dr. John Woodward, M.D., succinctly puts it, “For optimal benefits, DHEA should be used as a bioidentical DHEA cream, specifically Twist 25. Create your own hormones with Twist 25.” 

User Testimonials

“This cream has been remarkable for me! I’m 55 and was struggling BIG TIME… with lack of well being, lack of energy and lack of libido. From the first pump, I noticed something … albeit very small.. but within 3 weeks I am a different woman! I don’t feel the need for naps, my well being restored and my libido better than ever! This product is the REAL DEAL! I’m so thankful to have found this product! “

–Female, Age 55, Mont Vernon, New Hampshire

“DHEA is the most abundant base for hormones in our body. It is not a foreign substance. We make it and have it in our systems. So keep DHEA levels where they are when we are healthiest. It just makes sense.”
– Female, Medical Doctor, Dallas, Texas, Age 47

“I have received a wonderful blessing… Twist 25! I know some people throw around the phrase ‘blessing’, but I don’t. I finally am getting my life back. Here is a list of some of the great changes I have experienced so far: energy & depth, Results when I work out, Faster recovery after workouts, Feeling of “centeredness” or “well-being” in everyday life, soft hydrated skin, healthy hair, fast-growing fingernails, mental clarity, consistent sex drive, sound sleep

I‘ve been using Twist 25 for 5 years. I look forward to getting up every day, working out, and living a happier, healthier life!”

– Female, Julie W., Demoines, Iowa, Age 42

“I started using Twist 25 about 6 months ago, and it’s great. I started on a new health kick. Seems like I’m making more of life. I feel great… About 3 weeks after I started using Twist, I started exercising more and going to the gym ‘ I had a drive to do it – I worked out with my weights some, jogged a few times more than I usually do, and …..that’s it. I feel great. I’m productive at work. I sleep better at night. Twist 25 helps me thrive. It keeps me at my best.”
– Male, Age 43

“I have been using DHEA cream for 4 years and believe it has had an impact on the overall condition of my body at this age. I work out 4 times per week now. No one in the gym can believe I just turned 55 (she laughs). I have less than 10% body fat, and my muscles are defined…see (laughing)..and this guy at the gym told me I have the body of a 30-year-old.”(deep smile)
– Female, Marketing Consultant, Age 56

“I have been using Twist 25 for 4 years and I feel great. I have more energy, and my skin is softer. Also, I feel fit and trim and don’t have to work out as much as I used to to stay in shape. I recover faster after my workouts and benefit more. I have more energy, and I’m leaner. It’s amazing. I love it!”
– Female, Designer and Fashion Model, Age 49

“I’m 72 years old and have been taking DHEA for eleven years. My wife has been using DHEA for 18 years. We don’t take it for any major effect. It’s lots of subtle effects, not dramatic… DHEA is basic. The question is not whether we are going to live longer from DHEA supplementation. The question is: Will we live in a youthful state day to day? DHEA helps us maintain a higher quality life.”
– William Regelson, M.D. professor of medicine at the Medical College of Virginia

How to begin to use Twist 25 DHEA cream

As we’ve discussed earlier, to truly harness the benefits of DHEA supplementation, it’s imperative to use it correctly—as an absorbable skin cream. To embark on your Twist 25 DHEA cream journey, the first step is to cease using DHEA pills. Twist 25 DHEA cream is designed to maximize absorption and is widely available online, as well as from numerous healthcare providers and health supplement retailers across the U.S. 

Although Twist 25 DHEA cream might seem pricier compared to oral DHEA supplements, this is due to its formulation with premium pharmaceutical-grade ingredients. Manufactured in a facility adhering to Good Manufacturing Practices (GMP) and FDA regulations, Twist 25 undergoes rigorous laboratory testing to ensure its quality and efficacy. It’s crucial not to be misled by cheaper imitations. 

For optimal results, apply one or two pumps of Twist 25 DHEA cream onto thin, hairless skin and massage it in until it’s fully absorbed. Each pump delivers 25mg of pharmaceutical-grade bioidentical DHEA. 

Incorporate this routine into your daily life—apply the Twist 25 DHEA cream morning and evening, every day. It’s important to note that this product is for external use only. 

The best practice is to apply the cream after a warm bath or shower when your skin is clean, dry, and your pores are open. This ensures better absorption and efficacy. However, avoid sensitive areas like the skin near your eyes or mouth.

Making the right choice with Twist 25 DHEA cream vs Pills

For DHEA to deliver its array of health benefits effectively, application method is crucial. Using an absorbable skin cream like Twist 25 DHEA is highly recommended for both men and women aged 35 and over. Moreover, Twist 25 DHEA cream is known for its safety profile, with no reported dangerous side effects. 

Maintaining hormone balance with Twist 25 DHEA cream can help you both feel and look your best. As Dr. John Woodward, M.D., the brain behind Twist 25 DHEA cream, emphasizes, “DHEA should be applied through the bioidentical DHEA cream known as Twist 25. Use Twist 25 DHEA cream to enhance your hormone production naturally.”

References:

• Labrie F. et al Semin Reprod Med. 2004 Nov;22(4):299-309. Adrenal Androgens and Intracrinology. Source: Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada. [email protected]
• Hammer, Fabian, Subtil S, Lux P, Maser-Gluth C, Stewart P, et al “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and In Vitro Studies” Journal of Endocrinology and Metabolism. March 8 2005 pp 3600-3605) http://jcem.endojournals.org/content/90/6/3600.full.pdf

• Labrie, Fernand, Labrie C, “DHEA and intracrinology at menopause, a positive choice for evolution of the human species” Source: Climacteric – The Journal of the International Menopause Society. 2013 Apr;16(2):205-13. doi: 10.3109/13697137.2012.733983. Epub Nov 5, 2012. Pubmed https://pubmed.ncbi.nlm.nih.gov/23126249/