People determine the age and health of someone they meet within 10 seconds. Skin is a telltale sign people use to gauge overall health and age. Medical research now reveals why dehydroepiandrosterone (DHEA) drives this.
Hormone Decline and its Impact
After age 25, sex hormones begin a gradual decline. By age 35, both men and women begin to notice the effects of declining hormones in many different ways. Quality of sleep at night declines, as does energy, mood, muscle tone, sex drive and skin health. Declining hormone levels are strongly associated with many important health measures, such a cardiovascular health, bone strength, mental sharpness and muscle.
These are all signs of gradual hormone decline that we call aging. These unfortunate declines may be slowed or avoided by maintaining youthful DHEA levels, a crucial hormone precursor. Using DHEA as a properly made DHEA supplement cream called Twist 25 is key.
The Skin-DHEA Connection: Why it Matters
Skin, the dermis, is the largest organ of the human body. It is an external indicator of age and health. Medical research reveals why DHEA is so important to improve the health and appearance of skin.
How Does DHEA Anti aging Cream Benefit Skin?Six science-backed reasons:
- Boosts Sebum Production: DHEA is a base for “sebum.” Sebum is also known as skin oil. Sebum helps to keep the skin supple. It also has antimicrobial properties that keep irritations at bay. Sebum combines with lipids to hydrate skin and provide a protective barrier to keep harmful pathogens out and moisture in. So sebum allows for softer skin that is well hydrated and generally healthier.1
- Stimulates Collagen Production: In a 2000 clinical study, researchers determined that DHEA helps the body form collagen. Collagen is a protein important in connective tissue that gradually deteriorates as we age. As skin is depleted of collagen, it loses its elasticity and starts to look thin or “papery,” appearing to sag and wrinkle. At the same time this is occurring, collagenase enzymes speed up the process of collagen decline.2
- Inhibits Collagen Breakdown: DHEA not only helps the body produce collagen, but also helps to inhibit the production of collagenase, which breaks down collagen. With regular daily use of Twist 25 DHEA cream, users maintain strong healthy connective tissues, supporting healthy collagen in the dermis and yielding healthier, more youthful-looking skin.2
- Activates Collagen Genes: In addition, a 2008 Canadian study reinforced the findings of the 2000 study. In the 2008 study, researchers noted that DHEA cream appears to help the body “switch on” special genes that are responsible for collagen production.3
- Accelerates Wound Healing: DHEA has also been found to help skin wounds to heal faster.7
- Reduces Keratinocytes: DHEA also reduces the number of keratinocytes. Keratinocytes make skin rougher and cause formation of calluses. So, by using DHEA cream daily you can effectively keep skin smooth and soft.4
- Counteracts Cortisol: DHEA counterbalances cortisol. So, whereas cortisol breaks down skin and allows it to thin, DHEA has a beneficial building effect for skin and boosts the protective qualities of skin.
- Protects Against Carcinogens & Fades Age Spots: DHEA cream reduces the risk of both chemical and UV carcinogenson skin cells; and DHEA also fades keratoses or “age spots” or “liver spots.” 5,6
DHEA and the Skin: A Synergistic Relationship
The best way to use DHEA is as a cream, rather than a pill, because it is better absorbed and processed in the skin. The human body naturally metabolizes DHEA in the dermis. Twist 25 DHEA skin cream provides what the body uses naturally, bioidentical DHEA, where the body uses it, in the dermis or skin, the largest organ of the human body.
Twist 25 cream yields noticeable health benefits within a few weeks. DHEA is much less effective when taken as a pill because most DHEA is eliminated by the first-pass effect of the liver. Twist 25 DHEA Cream
Why DHEA Cream? DHEA Topical Cream Benefits Compared to a Pill
There are three (3) key medical reasons that DHEA is much better when it is used as an absorbable cream instead of a pill:
1. The First-Pass Effect
When you take DHEA orally as a pill, it’s largely filtered out by the liver—a process known as the “First-pass effect.” This means most of the beneficial DHEA never gets a chance to work. Instead, the liver converts it to DHEA-S (DHEA sulfate) rather than free DHEA. Free DHEA is essential as it’s the building block for sex hormones—both androgenic and estrogenic—which are crucial for helping you feel your best.
2. DHEA-S is Not the Same as Free DHEA
DHEA-S (Dehydroepiandrosterone sulfate) is not the same as free DHEA. Unlike DHEA, DHEA-S cannot be converted back into free DHEA by the body. However, DHEA can be converted into DHEA-S. For more detailed information on this topic, you can refer to an excellent medical research study.
(Hammer F, Subtil S, Lux P, Maser-Gluth C, Stewart P, et al. “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and In Vitro Studies.” Journal of Endocrinology and Metabolism, March 8, 2005, pp 3600-3605) http://jcem.endojournals.org/content/90/6/3600.full.pdf
3. DHEA Metabolizes in the Skin
Research indicates that the human body metabolizes most DHEA into various smaller, more specific hormones within the skin (the dermis). This suggests that the skin is a key area where DHEA metabolism occurs. Consequently, using Twist 25 DHEA cream, which provides bioidentical DHEA where it’s naturally utilized, can be highly effective.
DHEA also offers numerous skin-care benefits. It serves as a base for sebum, aids in collagen formation, and helps protect skin cells from UV radiation and chemical carcinogens. Dr. Fernand Labrie’s research at the University of Toronto School of Medicine introduced the concept of “intracrinology” the intracellular functions and interactions of extracellular signaling peptides or proteins like DHEA.
“In postmenopausal women, all estrogens, and most androgens are produced locally within peripheral target tissues from the adrenal steroid precursor DHEA. Similarly, in adult men, approximately 50% of androgens are made locally. Therefore, much of DHEA metabolism takes place inside skin cells when DHEA is applied topically.”
(Labrie F. et al., Semin Reprod Med. 2004 Nov;22(4):299-309. Adrenal androgens and intracrinology. Source: Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada. [email protected])
In summary, current medical research suggests that the most effective way to benefit from DHEA is through an absorbable skin cream.
Synergistic Health Benefits of DHEA
The benefits of DHEA for skin health are wonderful; but while anti aging DHEA is gently helping you look younger on the outside, it is also synergistically doing great things for your physiological health inside the body. That should really give you something to smile about, because you look your best when you feel your best. The healthy synergy of doing the right things shows.
Look your best and feel your best with Twist 25 DHEA cream.
Low DHEA levels are associated with many diseases of aging, such as cardiovascular disease, cancer, osteoporosis, depression, and dementia. So stay focused. Look sharp.
DHEA helps with muscle recovery after exercise, because DHEA aids in tissue formation and counteracts the inflammatory effects of cortisol. This means less soreness after your workouts and quicker rebuilding of shapely muscles, along with strong cartilage and bone. It also serves as a crucial precursor for sebum, keeping your skin hydrated and shielding skin cells from UV rays and harmful chemicals. Plus, DHEA plays a key role in stimulating the formation of connective tissue and cartilage, ensuring your body stays robust and resilient.
DHEA supports:
- Softer, more hydrated skin
- Boosting energy, focus, and mental clarity
- Strengthening the immune system
- Promoting lean muscle tone
- Improving bone strength
- Enhancing cardiovascular health
- Supporting libido and sexual performance
- Promoting deep REM sleep
DHEA reduces:
- Abdominal Fat
- Risk of Cancer
- Risk of Cardiovascular Disease
- Fatigue
- Depression
- Poor quality sleep
- Joint pain
- Muscle soreness
DHEA helps the body produce sebum; and sebum protects the skin and helps it to remain soft and well hydrated. DHEA helps skin form collagen which is the fabric of the skin that helps give it structure and support.
Twist 25: The Ideal DHEA Cream
DHEA is very safe to use and has no dangerous side effects. Twist 25 DHEA cream keeps skin looking youthful, soft, well-hydrated and vibrant, while it also reduces risks of both chemical and UV carcinogens and fades age spots.
How to Apply DHEA Cream
Apply a little Twist 25 DHEA cream daily to your face, neck and hands. Twist 25® DHEA Cream is a pharmaceutical-grade skin cream made with bioidentical DHEA, in an absorbable coconut oil base. It is made to deliver DHEA the right way, and the base delivery ingredient is coconut oil which also does great things to keep skin healthy and hydrated. Maintain young-looking, soft, beautiful skin while maintaining your hormones, collagen and sebum with Twist 25 DHEA cream.
FAQs about DHEA Cream
Is DHEA safe for long-term use?
Yes. Using DHEA cream is considered safe in the long run, as there are no significant side effects reported. DHEA is the most abundant naturally occurring pro-hormone in the human body.
Do men and women have different DHEA?
No. The DHEA molecule is identical for both men and women. While men typically produce more DHEA than women, the molecule itself remains the same. Generally, women’s levels peak at about 350-400, and men’s levels at 350-650. Here are the typical “normal” levels throughout life for men and women at different ages.
Will DHEA cream have adverse side effects?
There are no known severe side effects from using DHEA cream. However, it’s always wise to consult with your doctor before making any changes to your supplements and medications. It makes sense, considering DHEA is naturally occurring in the body and is unlikely to cause harm.
Can I use Twist 25 DHEA cream if I am taking medications?
Yes. DHEA, or dehydroepiandrosterone, is not a foreign substance but a naturally occurring pro-hormone in the body. It’s available over the counter without a prescription. However, Health2Go suggests consulting with your physician before using Twist 25 DHEA cream alongside other supplements.
How long does it usually take to get noticeable anti-aging results using DHEA face cream?
If used twice daily, you can expect to see beneficial results within 2-3 weeks.
If I use Twist 25 DHEA cream, will it cause me to make less of my own DHEA? Do I need to take breaks from using it?
No. DHEA is neither addictive nor habit-forming. Using DHEA cream doesn’t reduce your body’s natural DHEA production. If you stop using it, your body will resume its natural production. Therefore, breaks or holidays from the cream are unnecessary, and there are no dangerous side effects from daily use.
How does DHEA compare to other anti-aging approaches like Botox, fillers, or exfoliants? What about HGH?
Twist 25 DHEA cream helps your body utilize DHEA naturally in the skin, restoring youthful, soft skin. Unlike invasive procedures, it doesn’t introduce foreign substances into your body. HGH, or Human Growth Hormone, has documented risks and potential side effects and is also very costly. DHEA offers safer and more natural benefits.
Can DHEA cream be used on the face?
Yes. A small amount massaged gently onto the forehead, cheeks, and neck works wonders for a youthful look. However, avoid using the full application on the face and neck alone.
Keep it away from the eyes to prevent irritation. Twist 25 DHEA cream is meant for external use only.
Does DHEA cream improve skin elasticity and firmness?
Yes. Enhancements in skin collagen make the skin firmer and more toned, less thin and papery. Additionally, sebum helps hydrate the skin.
Can Twist 25 DHEA cream help with wrinkles and fine lines?
Yes. The increased sebum and collagen in the skin help gradually reduce and eliminate fine lines and wrinkles as we age.
Can DHEA cream help reduce age spots?
Yes. DHEA cream assists in fading age spots and keratoses.
Can I use Twist 25 DHEA cream if I am already using other anti-aging skin care products?
Yes; however, it is best to use Twist 25 DHEA cream alone and not mix it with other products to maintain its effectiveness. It’s formulated to work best by itself.
At what age should I start using Twist 25 DHEA cream for anti-aging benefits?
Health2Go generally recommends starting Twist 25 DHEA cream at around age 35, as most people produce sufficient DHEA until then.
Will DHEA cream affect my thyroid?
No. Twist 25 DHEA cream does not increase or decrease thyroid levels.
How long does a bottle of Twist 25 DHEA cream last?
A container of Twist 25 cream holds 50 ml of cream. Each full pump releases 0.5 ml, with 25 mg of DHEA per ml, making it a 5% DHEA cream. One bottle contains approximately 80 pumps.
If used twice daily, the container lasts about 40 days. It’s a good idea to prime the pump by giving it a firm thump on a countertop before each use.
Where can I buy top-quality DHEA cream?
You can purchase Twist 25 DHEA cream at https://twist25.com. There are also many other retail providers. If you have any questions, feel free to call 1-888-489-4782 and ask for Hugh Woodward. Health2Go is here to help!
Health2Go recommends a holistic approach to maintain health that includes a healthy diet, daily exercise, drinking plenty of water, sleeping 7-8 hours at night. A healthy holistic lifestyle with key lifestyle habits like Twist 25 DHEA cream allow for optimum anti-aging results.
Feel your best. Look your best, with Twist 25 DHEA cream.
References:
- “New Research Substantiates the Anti-AgingProperties of DHEA” Life Extension Magazine. December 2010, pg. 2
- Lee KS,Oh KY, Kim BC. “Effects ofdehydroepiandrosteron on collagen and collagenase gene expression by skinfibroplasts in culture. Journal of Dermatology Science. 2000 Jun;23(2):103-110.
- Calvo E, Luu The V., MorissetteJ., Martel C., Labrie C., Bernerd F, Deloche C., Chausade V., Leclaire J,Labrie F. “Pangenomic changes induced by DHEA in the skin of postmenopausalwomen” Journal of Steroid Biochem and Molecular Biology Dec 2008.
- Johanna M.Brandner, Sabine Kief,Christine Grund, Michael Rendl, Pia Houdek, Cecillia Kuhn, Erwin Tschachler,Werner W. Franke and Ingrid Moll. “Organization and formation of the tight junction system in human epidermis and cultured keratinocytes” European Journalof Cell Biology, Volume 81, Issue 5, May 2002, pages 253-263.
- Schwartz AG, Pashko LL. “Cancerchemoprevention with the adrenocortical steroid dehydroepiandrosterone andstructural analogs”. Journal of Cellular Biochemistry 1973; 17G: 73-79.
- Yang S, Fu Z, Wang F, Cao Y, Han R“Anti-mutagenicity activity of dehydroepiandrosteron”.
- Stuart J Mills, Jason J Ashworth, Stephen C Gilliver, Mathew J Hardman, Gillian S Ashcroft. “The Sex Steroid Precursor DHEA Accelerates Cutaneous Wound Healing Via the Estrogen Receptors”. Journal of Investigative Dermatology. Nov. 2005. Vol 125. Issue 5. Pg 1053-1062. https://www.jidonline.org/article/S0022-202X(15)32513-6/fulltext