Twist 25 DHEA cream for beautiful skin

Rejuvenate Your Skin with DHEA the Right Way: Enhancing Collagen

Medical research shows how dehydroepiandrosterone (DHEA) plays a pivotal role in enhancing collagen synthesis and metabolism, thereby driving skin health and vitality. DHEA cream is emerging as an effective strategy to improve collagen in the skin.
“You never get a second chance to make a first impression.”
This timeless adage underscores the significance of youthful, vibrant skin in shaping perceptions of age and health. People determine the age and health of someone they meet within 10 seconds. Skin is a telltale sign people use to gauge overall health and age.

Exploring Collagen Synthesis, Hormone Decline & DHEA Supplementation

As we age, starting around age 25, our bodies undergo a gradual decline in DHEA, which consequently leads to a decline in hormones, leading to various manifestations of aging and an increase in the risks of the diseases of aging such as cardiovascular health and cognitive function. Everything from diminished sleep quality to waning energy levels, mood swings, and thinning dry skin are noticeable changes that underscore the interplay between hormones and health.

By age 35, both men and women begin to notice the effects of declining hormones, that are strongly associated with critical health measures such as cardiovascular health, the immune system, bone strength, and mental sharpness.

However, maintaining youthful DHEA levels offers way to help mitigate these effects of declining hormones and boost collagen synthesis. DHEA is a crucial hormone precursor that plays a pivotal role in bolstering the production of sebum and collagen to help maintain skin firmness and elasticity. Using DHEA supplements, such as Twist 25, offers a strategic approach to counteract the signs of hormonal decline and promote vibrant, youthful skin.Skin’s Story & the Importance of DHEA

The Importance of DHEA for Skin

Skin or the dermis is the largest organ of the human body. It’s an external indicator of age and health. Medical research reveals why DHEA is so important to improve the health and appearance of skin.
boost collagen synthesis with dhea


  1. DHEA is a base for “sebum.” Sebum is also known as skin oil. Sebum helps to keep the skin supple, hydrated, soft. It also has antimicrobial properties that keep irritations at bay. The end result is brighter skin that is more hydrated, healthier and younger looking.1
  2. In a 2000 clinical study, researchers determined that DHEA helps the body produce collagen. Collagen is a protein important in connective tissue that gradually deteriorates as we age. As skin is depleted of collagen, it loses its elasticity and starts to look thin or “papery,” appearing to sag and wrinkle. At the same time this is occurring, collagenase enzymes speed up the process of collagen decline.2
  3. DHEA protects skin cells from ultraviolet sun light that can have damaging effects on skin cells and collagen synthesis; and DHEA also reduces risks of chemical carcinogens as well.

Collagen: The Fabric of Younger Skin

Collagen is the main protein in many structural supportive connective tissues in the body such as skin, cartilage, ligaments, tendons, and muscle. It consists of protein fibrils wound in a strong triple helical structure.

Understanding the intricate process of collagen synthesis is essential for appreciating the role of DHEA in skin health. Collagen constitutes at least 70% of the dry weight of human skin. Collagen is synthesized in the skin by dermal fibroblasts, linking amino acids into a sequence. Three alpha helix chains coil upon each other into a triple helical structure.

infographic on how collagen works
Shown above are illustrations of collagen fiber, a collagen molecule, and collagen amino acid sequence. The molecular structure of collagen. Three polypeptides coil to form tropocollagen. Tropocollagens bind together to form a fibril. Many fibrils bind together form a collagen fibre. Connective tissue















“Collagen is continuously turned over. Collagen fibrils break down in response to oxidative cell damage and in the course of normal cellular metabolism involving the enzyme collagenase. A loss of balance between production and destruction of collagen results in reduced tensile strength and formation of wrinkles. Collagen degradation is accelerated by poor diet and excessive sun exposure. Nutritional deficiencies, such as scurvy, and genetic mutations.” (

A diet rich in plant-based foods with lots of fresh colorful fruits and vegetables, herbs, nuts, beans, and whole grains; some seafood, dairy, poultry, and eggs; with occasional red meat is associated with healthy collagen production and good skin health.

DHEA not only helps the body produce collagen, but also helps to inhibit the production of collagenase, which breaks down collagen. With regular daily use of Twist 25 DHEA cream, users maintain strong healthy connective tissues, supporting healthy collagen in the dermis and yielding healthier, more youthful-looking skin.2

In addition, a 2008 Canadian study reinforced the findings of the 2000 study. In the 2008 study, researchers noted that DHEA cream appears to help the body “switch on” special genes that are responsible for collagen production.3

DHEA also reduces the number of keratinocytes. Keratinocytes make skin rougher and cause formation of calluses. So, by using DHEA cream daily you can effectively keep skin smooth and soft.4

DHEA cream reduces the risk of both chemical and UV carcinogens; and DHEA also fades keratoses or “age spots” or “liver spots.” 5,6

DHEA: A Pathway to Younger Looking Skin

When you consider the medical research, it is easy to understand how and why DHEA cream helps people have healthier, younger looking skin. The best way to use DHEA is as a cream, rather than a pill, because it is better absorbed and processed in the skin. DHEA protects the skin and helps skin to remain soft and well hydrated because DHEA is also a base for sebum, which is otherwise known as skin oil, that protects skin and keeps skin hydrated. Twist 25 DHEA cream is an even better way to get DHEA into the skin because the cream is made in a pharmaceutical grade coconut oil base cream with vitamin E and coenzyme Q-10 which are also well known to be great for the skin.

So, Twist 25 DHEA cream keeps skin looking youthful, soft, well-hydrated and vibrant, while it also reduces risks of both chemical and UV carcinogens and fades age spots. Twist 25 DHEA cream is very safe to use. It has no dangerous side effects.

Twist 25® DHEA cream is a pharmaceutical-grade skin cream made with bioidentical DHEA, in an absorbable coconut oil base. Apply a little Twist 25 DHEA cream daily to your face, neck and hands. Results may begin to be noticed within a few weeks of consistent topical application of the cream.

In conclusion, optimizing collagen synthesis through DHEA supplementation offers a holistic approach to maintaining youthful skin and overall well-being. By supporting hormonal balance and promoting collagen production, DHEA supplements like Twist 25 offer a strategic solution for combating the visible signs of aging and preserving skin health for years to come.

Feel your best and look your best with Twist 25 DHEA cream.


Hugh R. Woodward, MHA

Hugh Woodward is President/CEO of Health2Go, Inc. Health2Go makes and sells Twist 25 DHEA cream.
Hugh has a BBA in Business Management from University of Texas in Austin, Texas and an MHA, Master of Science in Health Care Administration.

Hugh is a subject matter expert on DHEA dedicating the past 20+ years of his life to studying the medical research about it. Hugh started Health2Go, Inc. in 2007 to research and develop the safest most effective DHEA supplement cream that can be made.

View profile

Leave a Comment

Your email address will not be published. Required fields are marked *

Shopping Cart