Sleep Better at Night With DHEA Cream

According to the Centers for Disease Control (CDC), more than ⅓ of Americans are sleep deprived, over 35% of adults in the United States get fewer than seven hours of sleep per night, and 1 in 20 Americans have fallen asleep at the wheel in the past month. Health experts suggest that adults should get at least seven hours of sleep per night. Unfortunately, seven hours of sleep may seem like an unattainable goal for many Americans.

More than half of the adults in the United States reported that they do not sleep soundly at night, instead tossing and turning, and frequently waking up throughout the night. Another 10 to 30% of adults suffer from chronic insomnia and struggle to fall asleep at night. The sleep epidemic not only impacts how well rested we feel, but the lack of rapid eye movement (REM) sleep has a direct impact on our mood, mental sharpness, productivity, and overall health. Medical research also now shows that poor sleep is associated with obesity.

REM sleep is the deepest level of sleep and is the level in which we dream and many of the body’s regenerating functions occur. Research suggests that poor sleep increases the risk of developing high blood pressure, cardiovascular disease, obesity, and type II diabetes.

To cope with sleeping disorders, many people turn to sleeping pills, purchase expensive special beds and pillows and rely on white noise, CPAP machines, and Breathe Right strips. While these are all viable remedies for sleeping disorders, they can be expensive and have unpleasant side effects. If you want to naturally improve your sleep patterns, then you should try DHEA cream, apply it especially in the evening.

Using a DHEA cream in the evening makes physiological sense for adults 35 and older because it aligns with the body’s natural hormonal rhythms, supports nighttime recovery, and helps compensate for age-related hormonal decline.

DHEA Declines after age 35

DHEA (dehydroepiandrosterone) production peaks in the mid-20s and begins a steady decline around age 35, leading to reduced levels of key downstream hormones such as estrogen and testosterone that influence energy, mood, and sleep regulation. A topical DHEA cream called Twist 25 can help restore youthful levels gently, especially during evening hours when endogenous production is lowest.

Evening Application Aligns with Hormone Rhythms

DHEA follows a circadian rhythm—naturally higher in the morning and lower at night. Applying DHEA cream in the evening supports the body’s nighttime DHEA trough, enhancing hormonal balance during rest. This synchronization can improve melatonin function, lower stress hormone (cortisol) levels at night, and promote deeper sleep stages such as REM and slow-wave sleep.

Improves Sleep and Nighttime Recovery

Research shows that supplementing or maintaining adequate DHEA levels increases REM sleep—a critical stage for memory, mood regulation, and physical restoration. DHEA also helps relax the nervous system and counteracts cortisol spikes that can cause restless sleep. For people over 35, whose natural DHEA and melatonin levels both tend to drop, applying a low-dose bioidentical DHEA cream may restore the hormonal balance necessary for restorative sleep.

People 35 and older should apply DHEA cream in the evening to help improve declining hormonal rhythms, and support melatonin and cortisol balance, to promote deeper, more rejuvenating sleep— while reducing the hormonal stress imbalance that can get worse with age.

What Is DHEA?

DHEA, or dehydroepiandrosterone, is a naturally occurring prohormone made and processed in the adrenal glands, gonads and dermis. DHEA is a base building block or hormone precursor for more than 50 hormones, including estrogen and testosterone. The body produces increasing amounts of DHEA from birth until about age 25, when we reach our “physical prime,” and decreases at a rate of about 2% each year thereafter. By age 35, most people produce about 20% less DHEA  than when they were age 25; and by age 50, people are making about half as much DHEA as when they were healthiest.

One of the many bodily functions DHEA affects is sleep. In fact studies have shown that DHEA naturally improves sleep and may help you achieve deeper REM sleep.

Improve REM Sleep with DHEA the right way

According to this study by Friess et al., “DHEA administration induced a significant (P<0.05) increase in rapid eye movement (REM) sleep, whereas all other sleep variables remained unchanged compared with placebo conditions.” In other words, research found that DHEA had a statistically significant impact on improved REM sleep. The study also found that people with higher levels of DHEA had deeper REM sleep, while people with lower DHEA levels had less REM sleep.

This suggests that using DHEA cream may help you sleep better at night, wake up feeling well rested and improve your mood, cognitive function, and energy level during the day. As a result of getting better sleep and feeling well rested, DHEA may help boost your overall mood and productivity and reduce major health risks  such as cardiovascular disease, diabetes and depression associated with sleep deprivation. 

How To Use DHEA

Benefits of topical application of DHEA cream

DHEA cream offers gradual absorption and avoids liver metabolism associated with oral supplements, providing stable hormone support overnight. This slow-release action aligns with the body’s sleep and recovery processes—supporting energy, immune balance, and mood upon waking. While it’s easy to find inexpensive oral DHEA supplements, oral DHEA supplements are minimally effective. It is important that DHEA be used correctly, as a properly made bioidentical DHEA cream called Twist 25 that is applied on thin hairless skin. A properly made pharmaceutical-grade bioidentical DHEA cream absorbed in the skin works best. DHEA is actually metabolized in the skin, so it’s better to use a DHEA cream over an oral supplement to get the most from your DHEA.

Oral DHEA supplements are largely eliminated by the liver, and the DHEA that enters the bloodstream is DHEA sulfate (DHEA-S) rather than free DHEA. DHEA-S is not bad for you; it’s just not as beneficial as free DHEA. Free DHEA is a hormone precursor to the sex hormones.  DHEA sulfate is not.

Twist 25 cream has no dangerous side effects and may provide noticeable results people feel, usually in just a few weeks.

• Sleep better
• Wake up feeling refreshed
• Have more energy
• Be in a better mood
• Lose belly fat

 Twist 25 DHEA cream is bioidentical DHEA cream that is made with a special coconut oil base, vitamin E and coenzyme Q-10. For best results, the cream should be rubbed twice daily onto thin, hairless skin. As mentioned above, the evening application is the most important for the sleep benefits.  Twist 25 DHEA cream has no dangerous side effects. Adding Twist 25 DHEA cream to your daily routine makes sense. Notice the benefits for deeper more restful sleep within a few weeks. Wake up feeling refreshed and sharper of mind with Twist 25. 

References:

“DHEA administration increases rapid eye movement sleep and EEG power in sigma frequency range.” Friess E, Trachsel L, Guldner J, Schier T, Steiger A, Holsboer F. American Journal of Physiology Jan 1995 268(1 Pt 1):E107-13. Pubmed study

https://pmc.ncbi.nlm.nih.gov/articles/PMC9210555/