Science shows why DHEA cream works for depression
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Science shows why DHEA cream works for depression
Happy healthy woman happy with the anti-aging benefits of Twist 25 DHEA cream

Science shows why DHEA cream works for depression

Medical research studies show that DHEA for depression works.

Hormones drive many aspects of our lives: how we feel, energy levels, mood, muscle
tone, fat build-up, sleep, sex drive, how productive we are, soft skin and more. There are myriad signs
we are getting older driven by declining hormone levels as we age.
The naturally occurring pro-hormone DHEA, short for dehydroepiandrosterone, is the most abundant foundation or base precursor from which the body makes hormones.

Levels of DHEA made by the body in the adrenal glands, sex organs and brain and skin gradually increase until about age 25, when we are “in our prime”; and then gradually decrease thereafter.

Human DHEA levels with age

Graph showing DHEA levels

After age 25 people make about 2% less DHEA each year.
So, by age 35 people make approximately 20% less DHEA than when they were 25; by age 50
people make about 50% less DHEA as when they were healthiest.

Dehydroepiandrosterone, DHEA, is a base for estrogen, testosterone, and 50 other hormones. DHEA also counterbalances cortisol helping to reduce negative effects of stress. DHEA is also a source for sebum and collagen synthesis in the skin. DHEA
metabolism occurs naturally in the skin, the dermis.

Research studies show that higher levels of DHEA makes people healthier and happier.
People with higher levels of DHEA have more energy, and thus get more done and are in a better mood.

Science shows DHEA “has significant anti-depressant effects. Providing the body with adequate levels of the pro-hormone, DHEA, after age 35 makes sense.

There are many clinical research studies published and available on the web. Just search
“dehydroepiandrosterone depression” showing DHEA helps fight depression. Many of these studies
can be found on PubMed. One study performed at the National Institute of Mental Health in
Rockville, Maryland concludes that “We find DHEA to be an effective treatment for treatment for
midlife-onset major and minor depression.” * (see link to article below)
Another study performed at University of Pittsburgh School of Medicine in 2010 concludes that
“…dehydroepiandrosterone has an important role in mood regulation and may have significant
antidepressant effects.”. * (see link to article below)
When hormone levels are maintained, mental sharpness, focus and zest for life and enjoyment of it
as well as memories of it can be maintained. Research studies show that DHEA can help
relieve depression that starts in middle age.

Higher DHEA levels correlated to reduced depression symptoms in half of the study participants.

Dr. John R. Woodward “It does make sense: The reason DHEA would have these anti-depressant effects is because
DHEA is the most abundant pro-hormone in the body, a naturally occurring base building block for hormones.
DHEA the right way. Method of administration: a special skin cream.”
Hence today known as Twist 25 DHEA cream.

DHEA also helps fend off many declines in physical fitness, mood and mental sharpness.

Science shows why Twist 25 DHEA cream makes sense DHEA helps fight
depression and keeps you healthy. Check it out!

DHEA in a coconut oil base cream is a natural and beneficial way to use
DHEA because DHEA metabolism occurs naturally in the skin.
Pubmed research study
Oral DHEA supplements are eliminated by the liver, and what little DHEA does enter the
bloodstream is DHEA sulfate not DHEA. DHEA-S is good, but not near as good or as beneficial as
DHEA. DHEA is actually processed by the body in the skin. So DHEA absorbed through the skin
is something the body can use applied where the body uses it.
That is why daily use of bioidentical DHEA cream Twist 25 is beneficial in many ways for
people 35 and up; but DHEA must be used as a properly made cream to work. Twist 25®DHEA cream is DHEA the right way and tested for proper mix and strength. Twist 25 cream
provides noticeable results people feel within just a few weeks.

improve mental sharpness
have more energy
fight depression
be more productive
 sleep better at night – deeper REM sleep

Listen to a great audio talk about DHEA cream via this link.

Here is a link to the Twist 25 DHEA cream product page

Here are links to the medical research discussed articles available on the web:

Wolkowitz OM, Reus VI, Roberts E, et al “Dehydroepiandrosteron (DHEA) Treatment of
Depression” Department of Psychiatry, University of California, San Francisco, School of Medicine
94143-0984, U.S.A. Feb 1, 1997https://pubmed.ncbi.nlm.nih.gov/9024954/

Schmidt PJ, Daly RC, et al “Dehydroepiandrosterone monotherapy in Midlife-onset Major and
Minor Depression” Behavioral Endocrinology Branch, National Institute of Mental Health,
Rockville, MD 20892-1276, U.S.A. Feb 2005
https://pubmed.ncbi.nlm.nih.gov/15699292/

G. Valenti, L. Ferrucci, F. Laurentani, G. Ceresini, S. Bandinelli, M. Luci, G. Ceda, M. Maggio, and R.S. Schwartz “Dehydroepiandrosterone sulfate and cognitive function in the elderly. The InCHIANTI Study” Journal of Endocrinology Invest. Oct 2009: 32(9): 766-772
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106776/

Stephenson K, et al “The Effects of compounded bioidentical transdermal hormone therapy on
hemostatic, inflammatory, immune factors; cardiovascular biomarkers; quality of life measures;and
healthoutcomes in perimenopausal and postmenopausal women.” Womens Wellness Center, Tyler,
Texas, U.S.A. Feb 17, 2013
https://pubmed.ncbi.nlm.nih.gov/23627249/

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