DHEA should be used as a properly made pharmaceutical grade bioidentical DHEA cream called “Twist 25” instead of a pill. DHEA is short for dehydroepiandrosterone. DHEA is a naturally occurring hormone precursor or pro-hormone. DHEA is a building block for other smaller hormones like testosterone and estrogen and 50 other smaller more specific carbon chain molecules. Hormones drive energy, mood, muscle tone, fat, quality of sleep, mental sharpness, immune system, sex drive, cardiovascular health, bone strength, brain health, skin and more.
Dr. John Woodward – “Twist 25 DHEA cream is the best DHEA supplement cream made. Medical research studies clearly show why DHEA is best used as a highly absorbable skin cream.”
There are 3 key reasons for this:
#1 When DHEA is taken orally as a pill, most DHEA is eliminated by the “First-pass effect” of the liver. Basically, this means that the liver filters out most of the effective DHEA before it can do any good; and what does end up increasing in the bloodstream is DHEA-S (DHEA sulfate) not free DHEA. Free DHEA is what is processed into the sex hormones, which are the hormones that help us to feel good.
#2 DHEA-S is not the same as free DHEA. DHEA-S is not converted by the body into free DHEA. DHEA can be converted into DHEA-S, but not the other way around.
(Hammer, Fabian, Subtil s, Lux P, Maser-Gluth C, Stewart P, et al “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and In Vitro Studies” Journal of Endocrinology and Metabolism. March 8 2005 pp 3600-3605) http://jcem.endojournals.org/content/90/6/3600.full.pdf
#3 Medical research shows the human body metabolizes most DHEA into various smaller more specific hormones in the skin (the dermis). The skin is where we metabolize much of the DHEA we make. So Twist 25 DHEA cream actually provides exactly what the body produces naturally (bioidentical DHEA) where it can be utilized (the skin). DHEA also has many skin-care benefits. DHEA is a base for sebum, helps with collagen formation, and protects skin cells from both UV and chemical carcinogens.
“In postmenopausal women, all estrogens and most androgens are made locally in peripheral target tissues from the inactive adrenal steroid precursor dehydroepiandrosterone (DHEA). In adult men, approximated 50% of androgens are made locally.”
(Labrie F. et al Semin Reprod Med. 2004 Nov;22(4):299-309. Adrenal androgens and intracrinology.
Source: Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada. firstname.lastname@example.org)
DHEA must be used as a bioidentical DHEA cream – Twist 25