DHEA Cream vs Pills: Why A DHEA Cream Supplement is Better

DHEA is short for dehydroepiandrosterone. It is the most abundant naturally occurring pro-hormone in the human body. It is not a foreign substance. It is a natural hormone precursor that only occurs in humans and upper-level primates. In this article we explore the main difference of DHEA cream vs pills and the DHEA cream supplement is more effective.

For people 35 and up, Twist 25 DHEA supplement cream is the best way to use DHEA to enjoy the many health benefits DHEA can provide.

DHEA was first identified in 1931 by Dr. Adolf Butenandt, who was awarded the Nobel Prize for Chemistry in 1939. Frequently called “the anti-aging hormone”, DHEA is a base for more than 50 hormones that are smaller or more specific carbon chain molecules in human biochemistry. As a precursor for all estrogenic and androgenic hormones, humans make DHEA naturally from birth.

DHEA is the most abundant foundation or base from which the body makes hormones. DHEA is produced and metabolized in the adrenal glands, gonads, and dermis. This is why using DHEA as an absorbable skin cream makes sense, rather than swallowing an oral DHEA supplement pill.

It is important to understand why using DHEA as a as properly made absorbable skin cream rather than a pill is much more effective. Let’s explore the science.

DHEA levels over the human lifespan

DHEA levels increase from birth through adolescence and puberty and peak between ages 20-25, when we are “in our prime”. Then DHEA levels gradually decrease by about 2% per year thereafter. So, by age 35, the body produces about 20% less DHEA than when we were “in our prime” at age 25; and by age 50, we produce 50% less DHEA than we did when we were in our twenties. This gradual decline continues.

Human DHEA levels with age
dhea cream vs pill chart











 Men and women produce more and more DHEA every year to about age 25 when levels are at their peak. After age 25, DHEA levels begin to decline at a rate of about two percent per year thereafter.

What does DHEA do?

One of the primary roles of DHEA is as a base hormone precursor. DHEA also supports the immune system, allowing for a greater number of and activity of natural killer (NK) cells. Low DHEA levels are associated with many diseases of aging, such as cardiovascular disease, cancer, osteoporosis, depression, and dementia.

DHEA promotes tissue formation after exercise, and counterbalances the inflammatory effects of cortisol. So it helps reduce soreness after workouts and helps us rebuild muscle, cartilage and bone. DHEA also serves as a base for sebum (skin oil), protecting skin cells from both UV and chemical carcinogens. In addition, DHEA stimulates the formation of connective tissue and cartilage and improves bone strength.

DHEA supports:

  • Energy, focus and mental acuity
  • Immune system
  • Lean muscle tone
  • Bone strength
  • Cardiovascular health
  • Libido and sexual performance
  • Deep REM sleep
  • Softer, more hydrated skin

DHEA reduces:

  • Abdominal Fat
  • Risk of Cancer-Risk of Cardiovascular Disease
  • Fatigue
  • Depression
  • Poor quality sleep
  • Joint pain
  • Muscle soreness

It is not possible to eat any particular foods to increase DHEA. DHEA supplementation is generally recommended for people 35 and up to maintain health.

DHEA Cream vs Pills: Why Twist 25 DHEA cream outperforms

As mentioned above, the human body naturally metabolizes DHEA in the dermis. Twist 25 cream provides what the body uses naturally, bioidentical DHEA, where the body used it, in the dermis or skin, the largest organ of the human body. Twist 25 cream yields noticeable benefits within a few weeks. DHEA is much less effective when taken as a pill because most DHEA is eliminated by the liver.

Reasons to Use Twist 25 DHEA Cream Instead of a Pill

There are 3 key reasons for this:

#1 When DHEA is taken orally as a pill, most DHEA is eliminated by the “First-pass effect” of the liver. Basically, this means that the liver filters out most of the effective DHEA before it can do any good; and what does end up increasing in the bloodstream is DHEA-S (DHEA sulfate), not free DHEA. Free DHEA is what is processed into the sex hormones, which are the hormones that help us to feel good.

#2 DHEA-S is not the same as free DHEA. It is not converted by the body into free DHEA. DHEA can be converted into DHEA-S, but not the other way around.

(Hammer, Fabian, Subtil s, Lux P, Maser-Gluth C, Stewart P, et al “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and In Vitro Studies” Journal of Endocrinology and Metabolism. March 8 2005 pp 3600-3605) http://jcem.endojournals.org/content/90/6/3600.full.pdf

#3 Medical research shows the human body metabolizes most DHEA into various smaller, more specific hormones in the skin (the dermis). The skin is where we metabolize much of the DHEA we make. So Twist 25 DHEA cream actually provides exactly what the body produces naturally, bioidentical DHEA where it can be utilized, the skin. DHEA also has many skin-care benefits because DHEA is a base for sebum, helps with collagen formation, and protects skin cells from both UV and chemical carcinogens.

“In postmenopausal women, all estrogens and most androgens are made locally in peripheral target tissues from the inactive adrenal steroid precursor dehydroepiandrosterone (DHEA). In adult men, approximately 50% of androgens are made locally.”

(Labrie F. et al Semin Reprod Med. 2004 Nov;22(4):299-309. Adrenal androgens and intracrinology.

Source: Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada. fernand.labrie@crchul.ulaval.ca)

So instead of wasting time and money on DHEA pills that have little or no noticeable benefit, use Twist 25 DHEA cream by rubbing it into thin hairless skin where it absorbs quickly and leaves no residue or odor.

Twist 25 DHEA cream is made with a pharmaceutical-grade coconut oil base cream and also contains coenzyme Q-10 and vitamin E. It contains all plant-sourced ingredients. It has no parabens, no lecithin, no cyclodextrin.

DHEA is the same hormone precursor in men as it is in women. It is simply a base that the body uses however it needs to. Obviously, men process it into different hormones than women do.

The body uses free DHEA as a precursor to the sex hormones, whereas DHEA sulfate does not. This is why people feel and notice the benefits of using Twist 25 DHEA cream instead of pills.

Twist 25 DHEA cream does cost a bit more than DHEA pills or imitation products. This is because Twist 25 DHEA cream contains pharmaceutical-grade ingredients compounded in an FDA-approved facility into a highly specialized cream that is tested for proper mix and strength. Each full pump press contains 25 MG of bioidentical DHEA. Noticeable benefits of DHEA cream begin to be felt within a few weeks of regular daily use.

DHEA is safe, is not addictive or habit-forming and has no dangerous side effects. DHEA is the most abundant naturally occurring prohormone in the human body.

Twist 25 DHEA cream is generally recommended for men or women aged 35 and up. Twist 25 DHEA cream has not been tested for use by women who are pregnant or nursing and has no dangerous side effects.

DHEA cream by Twist 25 is made and sold only in the U.S.A. No prescription is required. In some countries like Canada, France, and Australia, products containing DHEA require a physician’s prescription. Health2Go, Inc. can only accept orders from customers with a bill to address and ship to address in the U.S.A.

It is important to use Twist 25 DHEA cream properly to get the many benefits DHEA can provide.

As summarized by Dr. John Woodward, M.D. “DHEA must be used as a bioidentical DHEA cream called Twist 25. Use Twist 25 DHEA cream. Make your own hormones.”

User Testimonials

“DHEA is the most abundant base for hormones in our body. It is not a foreign substance. We make it and have it in our systems. So keep DHEA levels where they are when we are healthiest. It just makes sense.”
– Female, Medical Doctor, Dallas, Texas, Age 47

“I have received a wonderful blessing… Twist 25! I know some people throw around the phrase ‘blessing’, but I don’t. I finally am getting my life back. Here is a list of some of the great changes I have experienced so far: energy & depth, Results when I work out, Faster recovery after workouts, Feeling of “centeredness” or “well-being” in everyday life, soft hydrated skin, healthy hair, fast-growing fingernails, mental clarity, consistent sex drive, sound sleep

I‘ve been using Twist 25 for 5 years. I look forward to getting up every day, working out, and living a happier, healthier life!”

– Female, Julie W., Demoines, Iowa, Age 42

“I started using Twist 25 about 6 months ago, and it’s great. I started on a new health kick. Seems like I’m making more of life. I feel great… About 3 weeks after I started using Twist, I started exercising more and going to the gym ‘ I had a drive to do it – I worked out with my weights some, jogged a few times more than I usually do, and …..that’s it. I feel great. I’m productive at work. I sleep better at night. Twist 25 helps me thrive. It keeps me at my best.”
– Male, Age 43

“I have been using DHEA cream for 4 years and believe it has had an impact on the overall condition of my body at this age. I work out 4 times per week now. No one in the gym can believe I just turned 55 (she laughs). I have less than 10% body fat, and my muscles are defined…see (laughing)..and this guy at the gym told me I have the body of a 30-year-old.”(deep smile)
– Female, Marketing Consultant, Age 56

“I have been using Twist 25 for 4 years. I feel great. I have more energy, and my skin is softer. I feel fit and trim and don’t have to work out as much as I used to to stay in shape. I recover faster after my workouts and benefit more. I have more energy, and I’m leaner. It’s amazing. I love it!”
– Female, Designer and Fashion Model, Age 49

“I’m 72 years old and have been taking DHEA for eleven years. My wife has been using DHEA for 18 years. We don’t take it for any major effect. It’s lots of subtle effects, not dramatic… DHEA is basic. The question is not whether we are going to live longer from DHEA supplementation. The question is: Will we live in a youthful state day to day? DHEA helps us maintain a higher quality life.”
– William Regelson, M.D. professor of medicine at the Medical College of Virginia

How to begin to use Twist 25 DHEA cream

As explained above, to benefit from DHEA supplementation and actually feel the benefits, it is crucial to use DHEA the right way, as an absorbable skin cream. Stop using DHEA pills. Twist 25 DHEA cream is available to buy online as well as from many health care providers and health supplement retailers in the USA.

Apply one or two pump presses of Twist 25 DHEA cream onto thin hairless skin and rub in until the cream absorbs completely. Each full pump press from the pump bottle contains 25 MG pharmaceutical grade bioidentical DHEA.

Make it part of your daily routine. Twist 25 DHEA cream should be applied morning and evening every day. Twist 25 DHEA cream is for external use.

It’s a good thing to apply after a warm bath or shower when the skin is clean and dry; skin pores are open and clean, and blood flow is good. Avoid sensitive skin near the eyes or mouth.


DHEA must be used the right way to provide the many health benefits it can provide. It should be used as a properly made absorbable skin cream to work. Twist 25 DHEA cream is generally recommended for men and women aged 35 and up. Twist 25 DHEA cream has no dangerous side effects.

Use Twist 25 DHEA cream to maintain hormone balance to feel your best and look your best. As the inventor of Twist 25 DHEA cream, Dr. John Woodward, M.D., said, “DHEA must be used as a bioidentical DHEA cream called Twist 25. Use Twist 25 DHEA cream. Make your own hormones.”


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